Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | RB1 | P06400 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14818596 | 0.84 | CDK1 (0.40) | CDK1CCNB1CDK2CDK4CCND1 | |
| SCHEMBL16748648 | 0.81 | CDK1 (0.38) | CDK1CCNB1CDK2CDK4CCND1 | |
| SCHEMBL16748830 | 0.79 | CDK1 (0.37) | CDK1CCNB1CDK2CDK4CCND1 | |
| SCHEMBL9653085 | 0.73 | LOXL2 (0.48) | LMNA | |
| SCHEMBL15883997 | 0.72 | NPC1 (0.42) | CYP1A2CYP2C19 | |
| SCHEMBL15959300 | 0.69 | PTGDR2 (0.33) | CDK1CCNB1CDK2CDK4CCND1 | |
| SCHEMBL7915503 | 0.66 | CYP1A2 (0.42) | CYP1A2CYP2C9CYP2C19CA9GLA | |
| SCHEMBL12090766 | 0.66 | DAO (0.42) | CDK1CCNB1CDK2CDK4CCND1 | |
| SCHEMBL9915322 | 0.66 | CYP1A2 (0.34) | CYP1A2CYP2C9CYP2C19GLASMN1; SMN2 | |
| SCHEMBL6901164 | 0.66 | LMNA (0.40) | CYP1A2CYP2C9CYP2C19CA9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |