Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16747451 | 0.84 | ALDH1A1 (0.40) | TP53TSHRALDH1A1 | |
| SCHEMBL9915458 | 0.83 | TP53 (0.39) | TP53PTPN11S1PR3PLA2G2ATSHR | |
| SCHEMBL9915520 | 0.82 | NR1H4 (0.45) | TP53PTPN11TSHRHPGDPLA2G4B | |
| SCHEMBL9915434 | 0.80 | NR1H4 (0.44) | TP53PTPN11TSHR | |
| SCHEMBL9915355 | 0.79 | COMT (0.38) | TP53ALDH1A1 | |
| SCHEMBL16747452 | 0.78 | PTPRC (0.36) | CNR2 | |
| SCHEMBL15279057 | 0.76 | TP53 (0.33) | TP53PTPN11S1PR3TSHRALDH1A1 | |
| SCHEMBL9915322 | 0.76 | CYP1A2 (0.34) | TP53TSHRALDH1A1HPGD | |
| SCHEMBL9915301 | 0.76 | TDP1 (0.36) | TP53ALDH1A1PTPN1 | |
| SCHEMBL16748752 | 0.76 | TP53 (0.34) | TP53CNR2TSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | TP53 4737/4885PTPN11 3510/4885S1PR3 3452/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | TP53 4737/4885PTPN11 3510/4885S1PR3 3452/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | TP53 4737/4885PTPN11 3510/4885S1PR3 3452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.