Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 2/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16747352 | 0.92 | MEN1 (0.37) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL15279057 | 0.88 | TP53 (0.33) | MEN1KMT2AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL16747516 | 0.87 | CYP2C19 (0.41) | MEN1KMT2AALDH1A1L3MBTL1TSHR | |
| SCHEMBL9915331 | 0.78 | MEN1 (0.40) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL14136527 | 0.78 | PPARD (0.43) | TSHRPPARGHPGDLMNASMN1; SMN2 | |
| SCHEMBL22022461 | 0.77 | EGFR (0.41) | NPC1RAB9AHPGDLMNA | |
| SCHEMBL9915436 | 0.76 | FAAH (0.36) | ALDH1A1TSHRMAPK1 | |
| SCHEMBL16748752 | 0.76 | TP53 (0.34) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9915493 | 0.76 | SMN1; SMN2 (0.43) | NPC1RAB9AMEN1KMT2AHPGD | |
| SCHEMBL14136603 | 0.75 | USP2 (0.45) | MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | NPC1 3628/4885RAB9A 2614/4885MEN1 2023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.