Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 9/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15279017 | 0.84 | FAAH (0.33) | FAAHTSHRRECQLUSP2MAPK1 | |
| SCHEMBL14136933 | 0.82 | SMN1; SMN2 (0.34) | FAAHTSHRRECQLUSP2MAPK1 | |
| SCHEMBL16748752 | 0.80 | TP53 (0.34) | TSHRMAPK1ALDH1A1 | |
| SCHEMBL15279057 | 0.80 | TP53 (0.33) | TSHRMAPK1ALDH1A1 | |
| SCHEMBL14136527 | 0.78 | PPARD (0.43) | TSHR | |
| SCHEMBL14136603 | 0.77 | USP2 (0.45) | USP2MAPK1 | |
| SCHEMBL16748757 | 0.77 | S1PR2 (0.33) | TSHRALDH1A1 | |
| SCHEMBL9915381 | 0.76 | NPC1 (0.38) | TSHRMAPK1ALDH1A1 | |
| SCHEMBL9915493 | 0.76 | SMN1; SMN2 (0.43) | — | |
| SCHEMBL14136604 | 0.75 | USP2 (0.45) | USP2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |