Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915417 | 0.82 | PAX8 (0.48) | KMT2AALDH1A1KDM4ETDP1POLB | |
| SCHEMBL192397 | 0.76 | APLNR (0.56) | ALDH1A1ABCB1TSHRPOLBHTT | |
| SCHEMBL19280337 | 0.74 | ALDH1A1 (0.40) | KMT2AALDH1A1KDM4ETDP1ABCB1 | |
| SCHEMBL29194774 | 0.74 | MTNR1A (0.47) | ALDH1A1KDM4EACHEHTTSMN1; SMN2 | |
| SCHEMBL30855367 | 0.74 | MTNR1A (0.47) | ALDH1A1KDM4EACHEHTTSMN1; SMN2 | |
| SCHEMBL31564004 | 0.73 | ALDH1A1 (0.46) | KMT2AALDH1A1KDM4ETDP1TSHR | |
| SCHEMBL27410383 | 0.72 | MTNR1A (0.38) | KMT2AKDM4EMEN1SMN1; SMN2LMNA | |
| SCHEMBL192119 | 0.72 | ALDH1A1 (0.45) | KMT2AALDH1A1KDM4ETDP1TSHR | |
| SCHEMBL23692493 | 0.72 | NR1H3 (0.46) | ALDH1A1KDM4EABCB1TSHRPOLB | |
| SCHEMBL22579009 | 0.71 | APLNR (0.57) | KMT2AALDH1A1ABCB1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |