Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MDH1 | P40925 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14136603 | 0.92 | USP2 (0.45) | USP2MAPK1SMN1; SMN2THRBCREBBP | |
| SCHEMBL9915493 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTCYP1A2CYP2C9HPGD | |
| SCHEMBL9915389 | 0.83 | USP2 (0.39) | USP2MAPK1SMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL16748752 | 0.80 | TP53 (0.34) | MAPK1MAPTGAACYP1A2CYP2C9 | |
| SCHEMBL15279057 | 0.79 | TP53 (0.33) | MAPK1GAATHRBHPGD | |
| SCHEMBL9915325 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTCYP2C9HPGD | |
| SCHEMBL9915385 | 0.76 | WDR5 (0.48) | CYP2C19 | |
| SCHEMBL9915355 | 0.73 | COMT (0.38) | MAPTGAATHRBCYP1A2CYP2C9 | |
| SCHEMBL9915381 | 0.73 | NPC1 (0.38) | MAPK1SMN1; SMN2HPGD | |
| SCHEMBL15279017 | 0.72 | FAAH (0.33) | USP2MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | USP2 1536/4885MAPK1 4319/4885SMN1; SMN2 4574/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | USP2 1536/4885MAPK1 4319/4885SMN1; SMN2 4574/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | USP2 1536/4885MAPK1 4319/4885SMN1; SMN2 4574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.