Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19762907 | 0.80 | TAAR1 (0.55) | TAAR1PKMTRPA1TSHRAOC3 | |
| SCHEMBL9921646 | 0.80 | TAAR1 (0.54) | TAAR1TRPA1TSHRAOC3RIPK1 | |
| SCHEMBL9768615 | 0.78 | TAAR1 (0.53) | TAAR1PKMAOC3RIPK1SLC6A2 | |
| SCHEMBL4755511 | 0.77 | HRH1 (0.50) | TAAR1TRPA1TSHRSLC6A2SLC6A4 | |
| SCHEMBL8471234 | 0.76 | TRPA1 (0.48) | TAAR1TRPA1TSHRPBRM1CYP1A2 | |
| SCHEMBL7511093 | 0.75 | TAAR1 (0.59) | TAAR1PKMAOC3RIPK1SLC6A2 | |
| SCHEMBL7511084 | 0.75 | TAAR1 (0.59) | TAAR1PKMAOC3RIPK1SLC6A2 | |
| SCHEMBL2161771 | 0.74 | RIPK1 (0.50) | TAAR1TRPA1AOC3RIPK1 | |
| SCHEMBL14387186 | 0.74 | RIPK1 (0.50) | TAAR1TRPA1AOC3RIPK1 | |
| SCHEMBL5661323 | 0.74 | TAAR1 (0.57) | TAAR1PKMTRPA1AOC3RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180002316-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2018-01-04 | — | — | US | disclosed |
| US-20120149662-A1 | Heterocyclic Compounds as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002316-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | TAAR1 3094/4885PKM 3467/4885TRPA1 4856/4885 |
| US-20120149662-A1 | Heterocyclic Compounds as Janus Kinase Inhibitors | JAK2, JAK1, JAK3 | TAAR1 3091/4885PKM 674/4885TRPA1 3399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.