Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | APOB | P04114 | 1/20 | 0.38 |
| ▸ | MTTP | P55157 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924090 | 0.93 | APOB (0.40) | GRM4APOBMTTPEPHX2PRCP | |
| SCHEMBL9924069 | 0.91 | GRM4 (0.38) | GRM4APOBMTTPPRCPMEN1 | |
| SCHEMBL9924077 | 0.91 | GRM4 (0.38) | GRM4CHRM3UBE2MDCUN1D1CYP2D6 | |
| SCHEMBL9924332 | 0.90 | SLC6A9 (0.41) | GRM4EPHX2MEN1KMT2ASLC6A9 | |
| SCHEMBL9924257 | 0.90 | GRM5 (0.42) | APOBMTTPEPHX2MEN1ALDH1A1 | |
| SCHEMBL17206710 | 0.89 | MEN1 (0.38) | GRM4APOBMTTPEPHX2PRCP | |
| SCHEMBL9924333 | 0.89 | NPC1 (0.44) | GRM4MEN1KMT2ACRHR1PDE4A | |
| SCHEMBL9924330 | 0.87 | GRM5 (0.47) | MEN1ALDH1A1KMT2A | |
| SCHEMBL9924083 | 0.86 | NPC1 (0.44) | GRM4MEN1KMT2ACRHR1 | |
| SCHEMBL9924071 | 0.86 | KMT2A (0.43) | MEN1ALDH1A1KMT2ACRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |