Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924087 | 0.94 | HSD11B1 (0.39) | GRM4LMNAADORA3NPSR1ALDH1A1 | |
| SCHEMBL9924255 | 0.93 | GRM4 (0.36) | GRM4DRD2CHRM3ALDH1A1EPHX2 | |
| SCHEMBL9924256 | 0.92 | NPC1 (0.36) | GRM4DRD2CHRM3LMNAEPHX2 | |
| SCHEMBL9924070 | 0.91 | GRM4 (0.40) | GRM4UBE2MDCUN1D1CHRM3ALDH1A1 | |
| SCHEMBL9924329 | 0.90 | SLC6A9 (0.40) | LMNAADORA3ALDH1A1EPHX2SMN1; SMN2 | |
| SCHEMBL17206702 | 0.90 | CHRM1 (0.38) | GRM4DRD2ALDH1A1EPHX2KMT2A | |
| SCHEMBL9924228 | 0.90 | CHRM1 (0.38) | GRM4DRD2ALDH1A1EPHX2KMT2A | |
| SCHEMBL9924259 | 0.90 | CHRM1 (0.38) | GRM4DRD2ALDH1A1EPHX2KMT2A | |
| SCHEMBL9924331 | 0.90 | NPC1 (0.40) | LMNAALDH1A1EPHX2HTTSMN1; SMN2 | |
| SCHEMBL9924084 | 0.89 | GRM4 (0.35) | GRM4DRD2CHRM3LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |