Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924257 | 0.92 | GRM5 (0.42) | NPC1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL9924256 | 0.91 | NPC1 (0.36) | NPC1MEN1KMT2ARAB9AHSD17B10 | |
| SCHEMBL9924329 | 0.91 | SLC6A9 (0.40) | MAPTKMT2ACCR3CXCR6GRM5 | |
| SCHEMBL9924077 | 0.90 | GRM4 (0.38) | MAPTKMT2AMAPK1HTTALDH1A1 | |
| SCHEMBL9924258 | 0.87 | GRM5 (0.47) | NPC1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL9924259 | 0.87 | CHRM1 (0.38) | MAPTMEN1KMT2ACHRM1POLB | |
| SCHEMBL17206702 | 0.87 | CHRM1 (0.38) | MAPTMEN1KMT2ACHRM1POLB | |
| SCHEMBL9924228 | 0.87 | CHRM1 (0.38) | MAPTMEN1KMT2ACHRM1POLB | |
| SCHEMBL9924087 | 0.87 | HSD11B1 (0.39) | MAPTMEN1KMT2AHTTKDM4E | |
| SCHEMBL9924084 | 0.86 | GRM4 (0.35) | MAPTMEN1KMT2AMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |