Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924077 | 0.92 | GRM4 (0.38) | LMNAHSD17B10CHRM3KMT2ASLC6A9 | |
| SCHEMBL9924331 | 0.91 | NPC1 (0.40) | NPC1RAB9ALMNAHSD17B10MEN1 | |
| SCHEMBL9924255 | 0.90 | GRM4 (0.36) | CHRM3MEN1KMT2ASLC6A9SLC6A5 | |
| SCHEMBL9924228 | 0.90 | CHRM1 (0.38) | MEN1KMT2ADRD2GRM4EPHX2 | |
| SCHEMBL9924259 | 0.90 | CHRM1 (0.38) | MEN1KMT2ADRD2GRM4EPHX2 | |
| SCHEMBL17206702 | 0.90 | CHRM1 (0.38) | MEN1KMT2ADRD2GRM4EPHX2 | |
| SCHEMBL9924087 | 0.89 | HSD11B1 (0.39) | LMNAMEN1KMT2AL3MBTL1SLC6A9 | |
| SCHEMBL9924084 | 0.89 | GRM4 (0.35) | LMNACHRM3MEN1KMT2ATDP1 | |
| SCHEMBL9924254 | 0.88 | CHRM1 (0.39) | CHRM3MEN1KMT2AGRM4EPHX2 | |
| SCHEMBL9924329 | 0.86 | SLC6A9 (0.40) | LMNAKMT2AL3MBTL1SLC6A9EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |