Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Radiprodil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 known ✓ | Q05586 | 9/20 | 1.00 |
| ▸ | GRIN2B known ✓ | Q13224 | 9/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 7/20 | 1.00 |
| ▸ | GRIN3B | O60391 | 7/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 7/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 7/20 | 1.00 |
| ▸ | GRIN3A | Q8TCU5 | 7/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Radiprodil SCHEMBL29819486 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| Radiprodil SCHEMBL134435 | 0.99 | GRIN1 (0.98) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| Radiprodil SCHEMBL135546 | 0.99 | GRIN1 (0.98) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4577953 | 0.93 | GRIN1 (0.86) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4576956 | 0.92 | GRIN1 (0.84) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4412049 | 0.91 | GRIN1 (0.83) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4414151 | 0.91 | GRIN1 (0.83) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4550674 | 0.91 | GRIN1 (0.83) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL2264133 | 0.91 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4578785 | 0.90 | GRIN1 (0.82) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9387212-B2 | Methods for treating Parkinson's disease | UCB BIOPHARMA SPRL (BE) | 2016-07-12 | — | — | US | claimed |
| US-20120059034-A1 | NOVEL CRYSTALLINE HYDRATE, AMORPHOUS AND POLYMORPHIC FORMS OF DIHYDRO-BENZOXAZOLE-6-YL-ACETAMIDE DERIVATIVE AND PROCESSES FOR THEIR PREPARATION | RICHTER GEDEON NYRT. (HU) | 2012-03-08 | — | — | US | claimed |
| CN-102341392-A | Novel crystalline hydrate, amorphous and polymorphic forms of dihydro-benzoxazole-6-yl-acetamide derivative and processes for their preparation | RICHTER GEDEON NYRT | 2012-02-01 | — | — | CN | claimed |
| JP-2012500800-A | — | — | 2012-01-12 | — | — | JP | claimed |
| JP-2012500801-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2403850-A1 | NOVEL CRYSTALLINE HYDRATE, AMORPHOUS AND POLYMORPHIC FORMS OF DIHYDRO-BENZOXAZOLE-6-YL-ACETAMIDE DERIVATIVE AND PROCESSES FOR THEIR PREPARATION | Richter Gedeon Nyrt. (HU) | 2012-01-11 | — | — | EP | claimed |
| JP-2011527689-A | — | — | 2011-11-04 | — | — | JP | claimed |
| US-20110190347-A1 | METHODS FOR TREATING NEUROPATHIC PAIN | RICHTER GEDEON NYRT. | 2011-08-04 | — | — | US | claimed |
| US-20110190348-A1 | METHODS FOR TREATING CNS DISORDERS | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2011-08-04 | — | — | US | claimed |
| EP-2331097-A1 | METHODS FOR TREATING CNS DISORDERS | Richter Gedeon Nyrt. (HU) | 2011-06-15 | — | — | EP | claimed |
| WO-2010006020-A1 | NOVEL CRYSTALLINE FORM OF 2-[4(4-FLUORO-BENZYL)-PIPERIDINE-1-YL]-2-OXO-N-(2-OXO-2,3-DIHYDRO-BENZOXAZOL-6-YL)-ACETAMIDE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-01-14 | — | — | WO | claimed |
| US-20100010044-A1 | NOVEL CRYSTALLINE FORM OF 2-[4-(4-FLUORO-BENZYL)-PIPERIDINE-1-YL]-2-OXO-N-(2-OXO-2,3-DIHYDRO-BENZOXAZOL-6-YL)-ACETAMIDE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-01-14 | — | — | US | claimed |
| JP-4322113-B2 | — | — | 2009-08-26 | — | — | JP | claimed |
| US-7435744-B2 | Piperidine derivatives as NMDA receptor antagonists | GEDEON RICHTER VEGYESZETI GYAR RT (HU) | 2008-10-14 | — | — | US | claimed |
| EP-1409477-B1 | PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2008-09-17 | — | — | EP | claimed |
| JP-2005515968-A | — | — | 2005-06-02 | — | — | JP | claimed |
| CN-1556805-A | piperidine derivatives as NMDA receptor antagonists | ������ҩ������˾ | 2004-12-22 | — | — | CN | claimed |
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | UCB Biopharma SRL (BE) | 2004-08-12 | — | — | US | claimed |
| EP-1409477-A1 | PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2004-04-21 | — | — | EP | claimed |
| WO-2003010159-A1 | PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-02-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | GRIN1, GRIN2D, GRIN2C | GRIN1 1/4885GRIN2B 7/4885GRIN2D 2/4885 |
| US-20100010044-A1 | NOVEL CRYSTALLINE FORM OF 2-[4-(4-FLUORO-BENZYL)-PIPERIDINE-1-YL]-2-OXO-N-(2-OXO-2,3-DIHYDRO-BENZOXAZOL-6-YL)-ACETAMIDE | UACA, CANX, AQP4 | GRIN1 3414/4885GRIN2B 1866/4885GRIN2D 565/4885 |
| US-20110190348-A1 | METHODS FOR TREATING CNS DISORDERS | SLC1A2, SLC18A2, BDNF | GRIN1 105/4885GRIN2B 43/4885GRIN2D 13/4885 |
| US-20120059034-A1 | NOVEL CRYSTALLINE HYDRATE, AMORPHOUS AND POLYMORPHIC FORMS OF DIHYDRO-BENZOXAZOLE-6-YL-ACETAMIDE DERIVATIVE AND PROCESSES FOR THEIR PREPARATION | DHX35, DHX9, ABCG2 | GRIN1 3936/4885GRIN2B 3210/4885GRIN2D 938/4885 |
| US-20110190347-A1 | METHODS FOR TREATING NEUROPATHIC PAIN | P2RX4, P2RX3, P2RX5 | GRIN1 553/4885GRIN2B 372/4885GRIN2D 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.