Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 5/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.48 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.44 |
| ▸ | CASP7 | P55210 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9925972 | 0.77 | KDM4E (0.54) | KDM4ELMNAPOLBAGTR1HSD17B10 | |
| SCHEMBL20988857 | 0.77 | LMNA (0.55) | KDM4ELMNAPOLBAGTR1HSD17B10 | |
| SCHEMBL9925969 | 0.71 | KDM4E (0.68) | KDM4ELMNAPOLBAGTR1HSD17B10 | |
| SCHEMBL11998882 | 0.70 | KDM4E (0.60) | KDM4ELMNAPOLBAGTR1HSD17B10 | |
| SCHEMBL9925965 | 0.69 | KDM4E (0.55) | KDM4ELMNAPOLBAGTR1HSD17B10 | |
| SCHEMBL20989040 | 0.68 | KDM4E (0.43) | KDM4ELMNAPOLBAGTR1HSD17B10 | |
| SCHEMBL7852652 | 0.67 | ABCC9 (0.76) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL3320388 | 0.66 | KDM4E (0.75) | KDM4ELMNAPOLBAGTR1HSD17B10 | |
| SCHEMBL20989041 | 0.66 | ALDH1A1 (0.47) | KDM4ELMNAPOLBAGTR1HSD17B10 | |
| SCHEMBL20988856 | 0.65 | ALDH1A1 (0.56) | KDM4ELMNAPOLBAGTR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214824-A1 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. | 2012-08-23 | — | — | US | disclosed |
| US-20120214824-A1 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. | 2012-08-23 | — | — | US | disclosed |
| WO-2012078902-A2 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214824-A1 | PROTEOSTASIS REGULATORS | PSMG3, HSPA5, HSP90B1 | ABCC9 2104/4885ABCC8 1079/4885KCNJ11 4678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.