Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.52 |
| ▸ | HPGD | P15428 | 8/20 | 0.52 |
| ▸ | CASP1 | P29466 | 5/20 | 0.52 |
| ▸ | CASP7 | P55210 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 6/20 | 0.52 |
| ▸ | GAA | P10253 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9925971 | 0.82 | ALDH1A1 (0.45) | KDM4EPOLBLMNAAGTR1ALDH1A1 | |
| SCHEMBL12001639 | 0.82 | KDM4E (0.55) | KDM4EPOLBLMNAAGTR1ALDH1A1 | |
| SCHEMBL9900603 | 0.80 | KDM4E (0.51) | KDM4EPOLBLMNAAGTR1ALDH1A1 | |
| SCHEMBL11998882 | 0.78 | KDM4E (0.60) | KDM4EPOLBLMNAAGTR1ALDH1A1 | |
| SCHEMBL9925969 | 0.78 | KDM4E (0.68) | KDM4EPOLBLMNAAGTR1ALDH1A1 | |
| SCHEMBL9925966 | 0.77 | ABCC9 (0.48) | KDM4EPOLBLMNAAGTR1ALDH1A1 | |
| SCHEMBL20988857 | 0.76 | LMNA (0.55) | KDM4EPOLBLMNAAGTR1ALDH1A1 | |
| SCHEMBL3320388 | 0.73 | KDM4E (0.75) | KDM4EPOLBLMNAAGTR1ALDH1A1 | |
| SCHEMBL12135697 | 0.72 | KDM4E (0.76) | KDM4EPOLBLMNAAGTR1ALDH1A1 | |
| SCHEMBL9925965 | 0.70 | KDM4E (0.55) | KDM4EPOLBLMNAAGTR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214824-A1 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. | 2012-08-23 | — | — | US | disclosed |
| US-20120214824-A1 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. | 2012-08-23 | — | — | US | disclosed |
| WO-2012078902-A2 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214824-A1 | PROTEOSTASIS REGULATORS | PSMG3, HSPA5, HSP90B1 | KDM4E 2560/4885POLB 2511/4885LMNA 1401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.