SCHEMBL9929970

SCHEMBL9929970

O=C(CO)N1CC=C(c2cc3c(cc2F)N2C(=O)O[C@@H](CO)[C@@H]2C3)CC1

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 8/20 0.37
CDK9 P50750 8/20 0.37
WDR5 P61964 8/20 0.34
MAPK1 P28482 1/20 0.34
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
CYP2C19 P33261 1/20 0.33
BTK Q06187 1/20 0.32
KDM4E B2RXH2 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14069896 1.00 CCNT1 (0.37) CCNT1CDK9WDR5MAPK1MAOA
SCHEMBL4555118 0.90 MAOA (0.39) CCNT1CDK9WDR5MAPK1MAOA
SCHEMBL9930041 0.89 MAOB (0.47) CCNT1CDK9WDR5MAPK1MAOA
SCHEMBL9930385 0.88 CCNT1 (0.36) CCNT1CDK9WDR5MAPK1MAOA
SCHEMBL9930158 0.88 WDR5 (0.32) WDR5MAOAMAOBCYP2C19
SCHEMBL14069349 0.88 MAOA (0.39) CCNT1CDK9WDR5MAPK1MAOA
SCHEMBL9968668 0.88 CCNT1 (0.40) CCNT1CDK9WDR5MAOAMAOB
SCHEMBL9929656 0.88 MAOA (0.39) CCNT1CDK9WDR5MAPK1MAOA
SCHEMBL14069434 0.88 CDK9 (0.36) CCNT1CDK9WDR5MAPK1BTK
SCHEMBL9930610 0.88 CDK9 (0.36) CCNT1CDK9WDR5MAPK1BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12016835-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2024-06-25 US disclosed
US-11851443-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2023-12-26 US disclosed
US-20230285340-A1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP LLC (US) 2023-09-14 US disclosed
US-11547687-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2023-01-10 US disclosed
US-20220298173-A1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP, LLC (US) 2022-09-22 US disclosed
US-11261197-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2022-03-01 US disclosed
US-20210079017-A1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP, LLC (US) 2021-03-18 US disclosed
US-20210059966-A1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP, LLC (US) 2021-03-04 US disclosed
US-10759813-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2020-09-01 US disclosed
US-10744104-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2020-08-18 US disclosed
US-9120747-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2015-09-01 US disclosed
EP-2651896-B1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R & D IP LLC (US) 2015-08-12 EP disclosed
US-20140343138-A1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP, LLC (US) 2014-11-20 US disclosed
US-20140046053-A1 NEPRILYSIN INHIBITORS THERAVANCE, INC. (US) 2014-02-13 US disclosed
US-8586536-B2 Neprilysin inhibitors THERAVANCE, INC. (US) 2013-11-19 US disclosed
US-20130109639-A1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP, LLC 2013-05-02 US disclosed
US-20120157383-A1 NEPRILYSIN INHIBITORS THERAVANCE, INC. (US) 2012-06-21 US disclosed
US-20120157434-A1 Antimicrobial heterocyclic compounds for treatment of bacterial infections CSO of MicuRx Pharmaceuticals, Inc. 2012-06-21 US disclosed
US-20120157434-A1 Antimicrobial heterocyclic compounds for treatment of bacterial infections CSO of MicuRx Pharmaceuticals, Inc. 2012-06-21 US disclosed
WO-2008108988-A1 ANTIMICROBIAL HETEROCYCLIC COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS MICURX PHARMACEUTICALS, INC. (US) 2008-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285340-A1 NEPRILYSIN INHIBITORS MME, REN, ACE CCNT1 2280/4885CDK9 3847/4885WDR5 4199/4885
US-10759813-B2 Neprilysin inhibitors MME, REN, ACE CCNT1 2199/4885CDK9 4145/4885WDR5 4437/4885
US-20130109639-A1 NEPRILYSIN INHIBITORS MME, REN, ACE CCNT1 2280/4885CDK9 3847/4885WDR5 4199/4885
US-11547687-B2 Neprilysin inhibitors MME, REN, ACE CCNT1 2280/4885CDK9 3847/4885WDR5 4199/4885
US-11261197-B2 Neprilysin inhibitors MME, REN, ACE CCNT1 2199/4885CDK9 4145/4885WDR5 4437/4885
US-10744104-B2 Neprilysin inhibitors MME, REN, ACE CCNT1 2280/4885CDK9 3847/4885WDR5 4199/4885
US-20210079017-A1 NEPRILYSIN INHIBITORS MME, REN, ACE CCNT1 2199/4885CDK9 4145/4885WDR5 4437/4885
US-20140046053-A1 NEPRILYSIN INHIBITORS MME, REN, ACE CCNT1 2199/4885CDK9 4145/4885WDR5 4437/4885
US-20210059966-A1 NEPRILYSIN INHIBITORS MME, REN, ACE CCNT1 2280/4885CDK9 3847/4885WDR5 4199/4885
US-20120157383-A1 NEPRILYSIN INHIBITORS MME, REN, ACE CCNT1 2199/4885CDK9 4145/4885WDR5 4437/4885
US-20220298173-A1 NEPRILYSIN INHIBITORS MME, REN, ACE CCNT1 2166/4885CDK9 4217/4885WDR5 4487/4885
US-20120157434-A1 Antimicrobial heterocyclic compounds for treatment of bacterial infections NISCH, NOD1, NQO1 CCNT1 775/4885CDK9 1980/4885WDR5 3083/4885
US-20140343138-A1 NEPRILYSIN INHIBITORS MME, REN, ACE CCNT1 2280/4885CDK9 3847/4885WDR5 4199/4885
US-11851443-B2 Neprilysin inhibitors MME, REN, ACE CCNT1 2199/4885CDK9 4145/4885WDR5 4437/4885
US-12016835-B2 Neprilysin inhibitors MME, REN, ACE CCNT1 2280/4885CDK9 3847/4885WDR5 4199/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.