Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15309318 | 0.87 | LMNA (0.55) | POLBKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9931375 | 0.78 | POLB (0.52) | POLBKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9931372 | 0.77 | POLB (0.55) | POLBKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2872394 | 0.74 | POLB (0.58) | POLBKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2872397 | 0.74 | POLB (0.58) | POLBKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL246755 | 0.73 | LMNA (0.53) | POLBKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL246754 | 0.73 | LMNA (0.53) | POLBKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8356392 | 0.73 | POLB (0.56) | POLBKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1970389 | 0.73 | POLB (0.56) | POLBKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12649504 | 0.73 | POLB (0.60) | POLBKDM4ECYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170231942-A1 | FUMARATE ESTER DOSAGE FORMS | BANNER LIFE SCIENCES LLC | 2017-08-17 | — | — | US | disclosed |
| US-20170056360-A1 | FUMARATE ESTER DOSAGE FORMS | BANNER LIFE SCIENCES LLC | 2017-03-02 | — | — | US | disclosed |
| US-8778991-B2 | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use | XENOPORT, INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20120157523-A1 | PRODRUGS OF METHYL HYDROGEN FUMARATE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | XENOPORT, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157523-A1 | PRODRUGS OF METHYL HYDROGEN FUMARATE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | FH, MGMT, BHMT2 | POLB 1143/4885KDM4E 484/4885CYP1A2 260/4885 |
| US-20170231942-A1 | FUMARATE ESTER DOSAGE FORMS | FH, FAH, SDHB | POLB 2564/4885KDM4E 763/4885CYP1A2 231/4885 |
| US-20170056360-A1 | FUMARATE ESTER DOSAGE FORMS | FH, FAH, SDHB | POLB 2564/4885KDM4E 763/4885CYP1A2 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.