Sugi Predict

Sugi Predict / Compounds / Acetamide

Acetamide

Acetamide

SCHEMBL9934182

CC(N)=O.c1ncc2cn[nH]c2n1

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3C3 Q8NEB9 2/20 0.38
▸ ROCK1 Q13464 3/20 0.38
▸ ROCK2 O75116 2/20 0.38
▸ RET P07949 2/20 0.38
▸ LRRK2 Q5S007 2/20 0.38
▸ CHEK1 O14757 2/20 0.38
▸ AURKA O14965 2/20 0.38
▸ PLK4 O00444 1/20 0.38
▸ DAPK3 O43293 1/20 0.38
▸ MAP4K4 O95819 1/20 0.38
▸ CSF1R P07333 1/20 0.38
▸ FGFR1 P11362 1/20 0.38
▸ PDGFRA P16234 1/20 0.38
▸ LTK P29376 1/20 0.38
▸ KDR P35968 1/20 0.38
▸ MAP2K2 P36507 1/20 0.38
▸ FLT3 P36888 1/20 0.38
▸ CSNK1A1 P48729 1/20 0.38
▸ PRKX P51817 1/20 0.38
▸ CDK5 Q00535 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29359980 0.86 — —
SCHEMBL7772 0.86 — —
SCHEMBL30612360 0.84 RET (0.43) ROCK1ROCK2RETLRRK2CHEK1
Water SCHEMBL438450 0.84 RET (0.43) ROCK1ROCK2RETLRRK2CHEK1
Hydrochloric Acid SCHEMBL310498 0.84 RET (0.43) ROCK1ROCK2RETLRRK2CHEK1
Hydrochloric Acid SCHEMBL311528 0.84 RET (0.43) ROCK1ROCK2RETLRRK2CHEK1
SCHEMBL3882735 0.81 RET (0.38) RETLRRK2CHEK1AURKAPDPK1
Acetamide SCHEMBL28053745 0.75 DYRK1A (0.37) ROCK1ROCK2PDPK1TSHRNTRK1
Acetamide SCHEMBL9934069 0.75 RIPK1 (0.47) PIK3C3ROCK1ROCK2RETLRRK2
Acetamide SCHEMBL9934178 0.74 ENPP1 (0.31) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2655377-B1 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS GLENMARK PHARMACEUTICALS SA (CH) 2016-03-30 — — EP disclosed
US-9073955-B2 2-amino-4-arylthiazole compounds as TRPA1 antagonists GLENMARK PHARMACEUTICALS, S.A. (CH) 2015-07-07 — — US disclosed
US-8889862-B2 2-amino-4-arylthiazole compounds as TRPA1 antagonists GLENMARK PHARMACEUTICALS, S.A. (CH) 2014-11-18 — — US disclosed
US-20140051667-A1 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS GLENMARK PHARMACEUTICALS, S.A. (CH) 2014-02-20 — — US disclosed
US-20140045865-A1 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS GLENMARK PHARMACEUTICALS, S.A. (CH) 2014-02-13 — — US disclosed
US-8592398-B2 2-amino-4-arylthiazole compounds as TRPA1 antagonists GLENMARK PHARMACEUTICALS, S.A. (CH) 2013-11-26 — — US disclosed
EP-2655377-A1 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS Glenmark Pharmaceuticals S.A. (CH) 2013-10-30 — — EP disclosed
WO-2012085662-A1 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS GLENMARK PHARMACEUTICALS S.A. (CH) 2012-06-28 — — WO disclosed
US-20120157411-A1 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPAI ANTAGONISTS GLENMARK PHARMACEUTICALS, S.A. (CH) 2012-06-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120157411-A1 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPAI ANTAGONISTS TRPA1, TRPV1, TRPV2 PIK3C3 3840/4885ROCK1 4717/4885ROCK2 4650/4885
US-20140045865-A1 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS TRPA1, TRPV1, TRPV2 PIK3C3 4225/4885ROCK1 4645/4885ROCK2 4541/4885
US-20140051667-A1 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS TRPA1, TRPV1, TRPV2 PIK3C3 4225/4885ROCK1 4645/4885ROCK2 4541/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.