SCHEMBL9937458

SCHEMBL9937458

NC(=O)c1c(N)c(C(=O)c2ccccc2)n2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ RXFP1 Q9HBX9 1/20 0.62
▸ MAPT P10636 1/20 0.54
▸ PTK2B Q14289 1/20 0.53
▸ HTT P42858 1/20 0.50
▸ KMT2A Q03164 2/20 0.48
▸ FNTA P49354 1/20 0.48
▸ FNTB P49356 1/20 0.48
▸ MEN1 O00255 1/20 0.47
▸ ALDH1A1 P00352 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15452568 0.92 RXFP1 (0.67) RXFP1MAPTHTTKMT2AFNTA
SCHEMBL9937249 0.89 MAPT (0.53) RXFP1MAPTHTTKMT2AMEN1
SCHEMBL20164019 0.83 RXFP1 (0.50) RXFP1MAPTHTTKMT2AMEN1
SCHEMBL15452564 0.82 RXFP1 (0.73) RXFP1MAPTKMT2AMEN1ALDH1A1
SCHEMBL20164021 0.81 KDM4E (0.49) RXFP1MAPTHTTKMT2AMEN1
SCHEMBL9936723 0.80 KDM4E (0.55) RXFP1MAPTHTTKMT2AMEN1
SCHEMBL28222167 0.75 HTT (0.52) RXFP1MAPTHTTKMT2AFNTA
SCHEMBL20347928 0.72 MAPT (0.44) RXFP1MAPTHTTKMT2AMEN1
SCHEMBL29882847 0.72 MEN1 (0.45) MAPTHTTKMT2AMEN1ALDH1A1
SCHEMBL19465228 0.71 IDO1 (0.38) RXFP1MAPTFNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3304088-B1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LTD (GB) 2025-07-30 — — EP claimed
EP-3304088-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE Electrophoretics Limited (GB) 2018-04-11 — — EP claimed
US-9763947-B2 Casein kinase 1delta (CK1delta) inhibitors ELECTROPHORETICS LIMITED (GB) 2017-09-19 — — US claimed
WO-2016189163-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LIMITED (GB) 2016-12-01 — — WO claimed
US-20160058745-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED (GB) 2016-03-03 — — US claimed
EP-2651404-B1 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS ELECTROPHORETICS LTD (GB) 2015-10-14 — — EP claimed
US-20260091025-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LIMITED (GB) 2026-04-02 — — US disclosed
EP-4663754-A2 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE Electrophoretics Limited (GB) 2025-12-17 — — EP disclosed
US-12419871-B2 Biomolecules involved in Alzheimer's disease ELECTROPHORETICS LIMITED (GB) 2025-09-23 — — US disclosed
EP-3304088-B1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LTD (GB) 2025-07-30 — — EP disclosed
US-20180140585-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LIMITED (GB) 2018-05-24 — — US disclosed
EP-3304088-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE Electrophoretics Limited (GB) 2018-04-11 — — EP disclosed
US-9789111-B2 Casein kinase 1δ (CK 1δ) inhibitors ELECTROPHORETICS LIMITED (GB) 2017-10-17 — — US disclosed
US-20150209368-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED (GB) 2015-07-30 — — US disclosed
US-20140031547-A1 CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES ELECTROPHORETICS LIMITED 2014-01-30 — — US disclosed
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED 2014-01-16 — — US disclosed
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED 2014-01-16 — — US disclosed
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED 2014-01-16 — — US disclosed
EP-2651404-A2 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS Electrophoretics Limited (GB) 2013-10-23 — — EP disclosed
WO-2012080727-A2 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS ELECTROPHORETICS LIMITED (GB) 2012-06-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS CSNK1G1, CSNK1A1, CSNK1D RXFP1 2794/4885MAPT 56/4885PTK2B 302/4885
US-20260091025-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE PYGB, PACSIN2, PPP3CA RXFP1 3074/4885MAPT 25/4885PTK2B 482/4885
US-20150209368-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS CSNK1A1, CSNK1G1, CSNK1D RXFP1 2663/4885MAPT 60/4885PTK2B 283/4885
US-20140031547-A1 CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES CSNK1G1, CSNK1A1, CSNK1G3 RXFP1 3126/4885MAPT 24/4885PTK2B 344/4885
US-20160058745-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS CSNK1A1, CSNK1G1, CSNK1D RXFP1 2663/4885MAPT 60/4885PTK2B 283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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