SCHEMBL9936723

SCHEMBL9936723

NC(=O)c1c(N)c(C(=O)c2cccs2)n2ccccc12

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.55
▸ MEN1 O00255 1/20 0.55
▸ ALDH1A1 P00352 1/20 0.55
▸ POLB P06746 1/20 0.55
▸ GAA P10253 1/20 0.55
▸ KMT2A Q03164 1/20 0.55
▸ MAPT P10636 3/20 0.43
▸ NPC1 O15118 2/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ RXFP1 Q9HBX9 1/20 0.43
▸ HPGD P15428 1/20 0.41
▸ HTT P42858 1/20 0.41
▸ HPGDS O60760 1/20 0.41
▸ CDK2 P24941 1/20 0.39
▸ ADORA1 P30542 1/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15452412 0.83 RXFP1 (0.53) KDM4EMEN1ALDH1A1POLBGAA
SCHEMBL9937458 0.80 RXFP1 (0.62) MEN1ALDH1A1KMT2AMAPTRXFP1
SCHEMBL9937249 0.75 MAPT (0.53) KDM4EMEN1KMT2AMAPTRXFP1
SCHEMBL15452568 0.72 RXFP1 (0.67) MEN1ALDH1A1KMT2AMAPTRXFP1
SCHEMBL29882847 0.67 MEN1 (0.45) KDM4EMEN1ALDH1A1POLBGAA
SCHEMBL29140076 0.67 MEN1 (0.49) KDM4EMEN1ALDH1A1POLBGAA
SCHEMBL937615 0.65 — —
SCHEMBL120212 0.65 — —
SCHEMBL13203274 0.64 HTT (0.44) KDM4EMEN1ALDH1A1POLBGAA
SCHEMBL182010 0.64 CES2 (0.71) KDM4EMEN1ALDH1A1POLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3304088-B1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LTD (GB) 2025-07-30 — — EP claimed
EP-3304088-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE Electrophoretics Limited (GB) 2018-04-11 — — EP claimed
US-9763947-B2 Casein kinase 1delta (CK1delta) inhibitors ELECTROPHORETICS LIMITED (GB) 2017-09-19 — — US claimed
WO-2016189163-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LIMITED (GB) 2016-12-01 — — WO claimed
US-20160058745-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED (GB) 2016-03-03 — — US claimed
EP-2651404-B1 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS ELECTROPHORETICS LTD (GB) 2015-10-14 — — EP claimed
US-20260091025-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LIMITED (GB) 2026-04-02 — — US disclosed
EP-4663754-A2 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE Electrophoretics Limited (GB) 2025-12-17 — — EP disclosed
US-12419871-B2 Biomolecules involved in Alzheimer's disease ELECTROPHORETICS LIMITED (GB) 2025-09-23 — — US disclosed
EP-3304088-B1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LTD (GB) 2025-07-30 — — EP disclosed
US-20180140585-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LIMITED (GB) 2018-05-24 — — US disclosed
EP-3304088-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE Electrophoretics Limited (GB) 2018-04-11 — — EP disclosed
US-9789111-B2 Casein kinase 1δ (CK 1δ) inhibitors ELECTROPHORETICS LIMITED (GB) 2017-10-17 — — US disclosed
US-20140031547-A1 CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES ELECTROPHORETICS LIMITED 2014-01-30 — — US disclosed
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED 2014-01-16 — — US disclosed
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED 2014-01-16 — — US disclosed
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED 2014-01-16 — — US disclosed
EP-2651404-A2 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS Electrophoretics Limited (GB) 2013-10-23 — — EP disclosed
CN-103298460-A Casein kinase 1 delta (CK1 delta) inhibitors ELECTROPHORETICS LTD 2013-09-11 — — CN disclosed
WO-2012080727-A2 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS ELECTROPHORETICS LIMITED (GB) 2012-06-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS CSNK1G1, CSNK1A1, CSNK1D KDM4E 1362/4885MEN1 3434/4885ALDH1A1 2098/4885
US-20260091025-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE PYGB, PACSIN2, PPP3CA KDM4E 3304/4885MEN1 4544/4885ALDH1A1 4448/4885
US-20140031547-A1 CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES CSNK1G1, CSNK1A1, CSNK1G3 KDM4E 1436/4885MEN1 3661/4885ALDH1A1 2473/4885
US-20160058745-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS CSNK1A1, CSNK1G1, CSNK1D KDM4E 1332/4885MEN1 3207/4885ALDH1A1 2054/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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