SCHEMBL9937249

SCHEMBL9937249

NC(=O)c1c(N)c(C(=O)c2ccc(F)cc2)n2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.53
▸ KMT2A Q03164 2/20 0.52
▸ MEN1 O00255 1/20 0.52
▸ RXFP1 Q9HBX9 1/20 0.52
▸ LMNA P02545 1/20 0.52
▸ MAPK1 P28482 1/20 0.52
▸ HTT P42858 1/20 0.52
▸ KDM4E B2RXH2 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9937458 0.89 RXFP1 (0.62) MAPTKMT2AMEN1RXFP1HTT
SCHEMBL20164019 0.88 RXFP1 (0.50) MAPTKMT2AMEN1RXFP1LMNA
SCHEMBL20164021 0.85 KDM4E (0.49) MAPTKMT2AMEN1RXFP1LMNA
SCHEMBL18227081 0.83 MAPT (0.53) MAPTKMT2AMEN1LMNAMAPK1
SCHEMBL15452568 0.82 RXFP1 (0.67) MAPTKMT2AMEN1RXFP1HTT
SCHEMBL28222179 0.78 KMT2A (0.51) MAPTKMT2AMEN1RXFP1LMNA
SCHEMBL9936723 0.75 KDM4E (0.55) MAPTKMT2AMEN1RXFP1MAPK1
SCHEMBL15452564 0.73 RXFP1 (0.73) MAPTKMT2AMEN1RXFP1KDM4E
SCHEMBL28222883 0.72 POLB (0.54) MAPTKMT2AMEN1LMNAMAPK1
SCHEMBL29635287 0.72 MEN1 (0.50) MAPTKMT2AMEN1LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3304088-B1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LTD (GB) 2025-07-30 — — EP claimed
EP-3304088-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE Electrophoretics Limited (GB) 2018-04-11 — — EP claimed
US-9763947-B2 Casein kinase 1delta (CK1delta) inhibitors ELECTROPHORETICS LIMITED (GB) 2017-09-19 — — US claimed
WO-2016189163-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LIMITED (GB) 2016-12-01 — — WO claimed
CN-105920010-A Casein Kinase 1delta (ck 1delta) Inhibitors 电泳有限公司 2016-09-07 — — CN claimed
CN-103298460-B Casein kinase 1(CK1) inhibitors ELECTROPHORETICS LTD. (GB) 2016-06-01 — — CN claimed
US-20160058745-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED (GB) 2016-03-03 — — US claimed
EP-2651404-B1 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS ELECTROPHORETICS LTD (GB) 2015-10-14 — — EP claimed
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED 2014-01-16 — — US claimed
EP-2651404-A2 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS Electrophoretics Limited (GB) 2013-10-23 — — EP claimed
CN-103298460-A Casein kinase 1 delta (CK1 delta) inhibitors ELECTROPHORETICS LTD 2013-09-11 — — CN claimed
WO-2012080727-A2 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS ELECTROPHORETICS LIMITED (GB) 2012-06-21 — — WO claimed
US-20260091025-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LIMITED (GB) 2026-04-02 — — US disclosed
EP-4663754-A2 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE Electrophoretics Limited (GB) 2025-12-17 — — EP disclosed
US-12419871-B2 Biomolecules involved in Alzheimer's disease ELECTROPHORETICS LIMITED (GB) 2025-09-23 — — US disclosed
EP-3304088-B1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE ELECTROPHORETICS LTD (GB) 2025-07-30 — — EP disclosed
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS ELECTROPHORETICS LIMITED 2014-01-16 — — US disclosed
EP-2651404-A2 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS Electrophoretics Limited (GB) 2013-10-23 — — EP disclosed
CN-103298460-A Casein kinase 1 delta (CK1 delta) inhibitors ELECTROPHORETICS LTD 2013-09-11 — — CN disclosed
WO-2012080727-A2 CASEIN KINASE 1DELTA (CK1DELTA) INHIBITORS ELECTROPHORETICS LIMITED (GB) 2012-06-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018540-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS CSNK1G1, CSNK1A1, CSNK1D MAPT 56/4885KMT2A 695/4885MEN1 3434/4885
US-20260091025-A1 BIOMOLECULES INVOLVED IN ALZHEIMER'S DISEASE PYGB, PACSIN2, PPP3CA MAPT 25/4885KMT2A 3313/4885MEN1 4544/4885
US-20160058745-A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS CSNK1A1, CSNK1G1, CSNK1D MAPT 60/4885KMT2A 656/4885MEN1 3207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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