Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30479913 | 0.82 | HDAC1 (0.56) | MEN1KMT2AKDM4EHDAC1NPC1 | |
| SCHEMBL14303852 | 0.82 | ASIC3 (0.50) | MEN1KMT2AKDM4EHDAC1NPC1 | |
| SCHEMBL2326260 | 0.82 | HDAC1 (0.56) | MEN1KMT2AKDM4EHDAC1NPC1 | |
| SCHEMBL4538231 | 0.81 | ASIC3 (0.53) | MEN1KMT2AKDM4EHDAC1NPC1 | |
| SCHEMBL13568532 | 0.81 | HDAC1 (0.60) | MAPKAPK2HDAC1KDM1AHDAC6TGFBR1 | |
| SCHEMBL730405 | 0.80 | CCR1 (0.42) | KDM4ERAB9AALDH1A1IDH1 | |
| SCHEMBL29387096 | 0.80 | CCR1 (0.42) | KDM4ERAB9AALDH1A1IDH1 | |
| SCHEMBL30259309 | 0.78 | CCR1 (0.41) | KDM4ERAB9AKDM1AALDH1A1IDH1 | |
| SCHEMBL30259554 | 0.78 | CCR1 (0.41) | KDM4ERAB9AKDM1AALDH1A1IDH1 | |
| SCHEMBL3361759 | 0.78 | HDAC1 (0.44) | HDAC1KDM1AHDAC6LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10426762-B2 | Inhibitors of hepatitis C virus polymerase | COCRYSTAL PHARMA, INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-20170273962-A1 | Inhibitors of Hepatitis C Virus Polymerase | COCRYSTAL PHARMA, INC. | 2017-09-28 | — | — | US | disclosed |
| US-9707215-B2 | Inhibitors of hepatitis C virus polymerase | COCRYSTAL, DISCOVERY, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150182514-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | COCRYSTAL PHARMA, INC. | 2015-07-02 | — | — | US | disclosed |
| US-20140322165-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | COCRYSTAL DISCOVERY INC (US) | 2014-10-30 | — | — | US | disclosed |
| US-8771665-B2 | Inhibitors of hepatitis C virus polymerase | COCRYSTAL DISCOVERY, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8729271-B2 | Glycine transporter inhibiting substances | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2014-05-20 | — | — | US | disclosed |
| US-8729271-B2 | Glycine transporter inhibiting substances | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2014-05-20 | — | — | US | disclosed |
| US-8729271-B2 | Glycine transporter inhibiting substances | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2014-05-20 | — | — | US | disclosed |
| WO-2014055142-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | COCRYSTAL DISCOVERY, INC. (US) | 2014-04-10 | — | — | WO | disclosed |
| EP-2651906-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | Cocrystal Discovery, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2617715-A1 | GLYCINE TRANSPORTER INHIBITOR | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2013-07-24 | — | — | EP | disclosed |
| EP-2617715-A1 | GLYCINE TRANSPORTER INHIBITOR | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2013-07-24 | — | — | EP | disclosed |
| US-20130184460-A1 | GLYCINE TRANSPORTER INHIBITING SUBSTANCES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-07-18 | — | — | US | disclosed |
| US-20130184460-A1 | GLYCINE TRANSPORTER INHIBITING SUBSTANCES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-07-18 | — | — | US | disclosed |
| US-20130184460-A1 | GLYCINE TRANSPORTER INHIBITING SUBSTANCES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-07-18 | — | — | US | disclosed |
| US-20120183496-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | COCRYSTAL DISCOVERY, INC. (US) | 2012-07-19 | — | — | US | disclosed |
| WO-2012083105-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | COCRYSTAL DISCOVERY, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| CN-100448846-C | Method for catalytic hydrogenation of acyl pyridine to preparing substituted pyridine compound hydrochlorate | UNIV TSINGHUA (CN) | 2009-01-07 | — | — | CN | disclosed |
| CN-1995017-A | Method for catalytic hydrogenation of acyl pyridine to preparing substituted pyridine compound hydrochlorate | UNIV TSINGHUA (CN) | 2007-07-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130184460-A1 | GLYCINE TRANSPORTER INHIBITING SUBSTANCES | SLC1A2, SLC18A2, SLC6A1 | MEN1 2952/4885KMT2A 3110/4885KDM4E 4469/4885 |
| US-10426762-B2 | Inhibitors of hepatitis C virus polymerase | POLR2E, POLR2H, GTF3C3 | MEN1 4805/4885KMT2A 3778/4885KDM4E 3082/4885 |
| US-20120183496-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | POLR2A, POLR2B, POLR2E | MEN1 4122/4885KMT2A 2421/4885KDM4E 2970/4885 |
| US-20150182514-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | POLR2E, POLR2H, GTF3C3 | MEN1 4805/4885KMT2A 3778/4885KDM4E 3082/4885 |
| US-20170273962-A1 | Inhibitors of Hepatitis C Virus Polymerase | POLR2E, POLR2H, GTF3C3 | MEN1 4805/4885KMT2A 3778/4885KDM4E 3082/4885 |
| US-20140322165-A1 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE | POLR2A, POLR2B, POLR2E | MEN1 4122/4885KMT2A 2421/4885KDM4E 2970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.