Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9944248 | 0.95 | RORC (0.51) | MAPTALDH1A1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL1458647 | 0.90 | PKM (0.57) | MAPTALDH1A1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL1457744 | 0.90 | MAPT (0.61) | MAPTALDH1A1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL1458345 | 0.86 | ALDH1A1 (0.58) | MAPTALDH1A1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL9944212 | 0.85 | TAS1R3 (0.60) | MAPTALDH1A1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL9944339 | 0.85 | MAPT (0.50) | MAPTALDH1A1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL9944216 | 0.85 | TAS1R3 (0.56) | MAPTALDH1A1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL1459229 | 0.84 | PKM (0.52) | MAPTALDH1A1MAPK1LMNATP53 | |
| SCHEMBL9944197 | 0.82 | TAS1R3 (0.52) | MAPTALDH1A1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL9944252 | 0.82 | RORC (0.50) | MAPTALDH1A1MAPK1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149737-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | KING'S COLLEGE LONDON (GB) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149737-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | RARA, RARB, RARG | MAPT 150/4885ALDH1A1 128/4885MAPK1 1666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.