Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 9/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.83 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24404688 | 1.00 | TSHR (0.83) | TSHRALDH1A1CYP3A4TP53HIF1A | |
| SCHEMBL12761985 | 0.96 | TSHR (0.82) | TSHRALDH1A1CYP3A4TP53HIF1A | |
| SCHEMBL2921943 | 0.96 | TSHR (0.74) | TSHRALDH1A1CYP3A4TP53HIF1A | |
| SCHEMBL17449872 | 0.96 | TSHR (0.82) | TSHRALDH1A1CYP3A4TP53HIF1A | |
| SCHEMBL9945692 | 0.96 | TSHR (0.74) | TSHRALDH1A1CYP3A4TP53HIF1A | |
| SCHEMBL9945690 | 0.96 | TSHR (0.74) | TSHRALDH1A1CYP3A4TP53HIF1A | |
| SCHEMBL14129252 | 0.96 | TSHR (0.82) | TSHRALDH1A1CYP3A4TP53HIF1A | |
| SCHEMBL24240744 | 0.94 | TSHR (0.79) | TSHRALDH1A1CYP3A4TP53HIF1A | |
| SCHEMBL12082299 | 0.94 | TSHR (0.79) | TSHRALDH1A1CYP3A4TP53HIF1A | |
| SCHEMBL26002003 | 0.93 | TSHR (0.78) | TSHRALDH1A1CYP3A4TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981068-B2 | Polymers which resist bacterial attachment | THE UNIVERSITY OF NOTTINGHAM (GB) | 2018-05-29 | — | — | US | disclosed |
| US-20140314826-A1 | NOVEL POLYMERS WHICH RESIST BACTERIAL ATTACHMENT | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-10-23 | — | — | US | disclosed |
| US-20140314826-A1 | NOVEL POLYMERS WHICH RESIST BACTERIAL ATTACHMENT | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-10-23 | — | — | US | disclosed |
| US-8808681-B2 | Crosslinked, degradable polymers and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-08-19 | — | — | US | disclosed |
| US-8808681-B2 | Crosslinked, degradable polymers and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-08-19 | — | — | US | disclosed |
| US-8562966-B2 | End-modified poly(beta-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-10-22 | — | — | US | disclosed |
| US-8562966-B2 | End-modified poly(beta-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-10-22 | — | — | US | disclosed |
| US-8318795-B2 | Antioxidant polymers containing [1,2]-dithiolane moieties and uses thereof | CEDARS-SINAI MEDICAL CENTER (US) | 2012-11-27 | — | — | US | disclosed |
| US-RE43612-E1 | Biodegradable poly(β-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-08-28 | — | — | US | disclosed |
| US-RE43612-E1 | Biodegradable poly(β-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-08-28 | — | — | US | disclosed |
| US-20100098653-A1 | ANTIOXIDANT POLYMERS CONTAINING [1,2]-DITHIOLANE MOIETIES AND USES THEREOF | CEDARS-SINAI MEDICAL CENTER (US) | 2010-04-22 | — | — | US | disclosed |
| US-20080242626-A1 | End-Modified Poly(beta-amino esters) and Uses Thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-10-02 | — | — | US | disclosed |
| US-20080242626-A1 | End-Modified Poly(beta-amino esters) and Uses Thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-10-02 | — | — | US | disclosed |
| US-7427394-B2 | Delivering labile agents; buffering effect; transfecting nucleic acids; nontoxic | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-09-23 | — | — | US | disclosed |
| US-7427394-B2 | Delivering labile agents; buffering effect; transfecting nucleic acids; nontoxic | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-09-23 | — | — | US | disclosed |
| WO-2008109105-A2 | METHODS AND COMPOSITIONS FOR IMPROVED THERAPEUTIC EFFECTS WITH SIRNA | FLAGSHIP VENTURES (US) | 2008-09-12 | — | — | WO | disclosed |
| US-20080145338-A1 | Acrylate-terminated poly(beta-amino esters); high throughput assay; biocompatability | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-06-19 | — | — | US | disclosed |
| US-20080145338-A1 | Acrylate-terminated poly(beta-amino esters); high throughput assay; biocompatability | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-06-19 | — | — | US | disclosed |
| WO-2008011561-A2 | END-MODIFIED POLY(BETA-AMINO ESTERS) AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-01-24 | — | — | WO | disclosed |
| WO-2007143659-A2 | CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080145338-A1 | Acrylate-terminated poly(beta-amino esters); high throughput assay; biocompatability | ACP1, ILK, BCAT2 | TSHR 4541/4885ALDH1A1 891/4885CYP3A4 1408/4885 |
| US-20080242626-A1 | End-Modified Poly(beta-amino esters) and Uses Thereof | PARN, PARG, POLL | TSHR 4517/4885ALDH1A1 2664/4885CYP3A4 3739/4885 |
| US-20100098653-A1 | ANTIOXIDANT POLYMERS CONTAINING [1,2]-DITHIOLANE MOIETIES AND USES THEREOF | GPX1, GPX4, LPO | TSHR 3898/4885ALDH1A1 172/4885CYP3A4 2888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.