Sugi Predict

Sugi Predict / Compounds / SCHEMBL9946050

SCHEMBL9946050

SCHEMBL9946050

CB(C)c1ccccc1OCc1ccccc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LIPE Q05469 1/20 0.73
▸ MAPT P10636 1/20 0.58
▸ MAPK1 P28482 1/20 0.58
▸ TDP1 Q9NUW8 1/20 0.58
▸ L3MBTL1 Q9Y468 1/20 0.58
▸ ENPP2 Q13822 1/20 0.51
▸ HTR1A P08908 6/20 0.50
▸ DRD2 P14416 1/20 0.50
▸ LTA4H P09960 1/20 0.47
▸ MAPK14 Q16539 1/20 0.47
▸ ADRA1D P25100 4/20 0.46
▸ ADRA1A P35348 4/20 0.46
▸ ADRA1B P35368 4/20 0.46
▸ BRD4 O60885 2/20 0.46
▸ HTT P42858 2/20 0.46
▸ GAA P10253 1/20 0.46
▸ STAT3 P40763 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ ALPG P10696 1/20 0.46
▸ PTK2B Q14289 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9946048 0.87 LIPE (0.57) LIPEMAPTMAPK1TDP1L3MBTL1
SCHEMBL9946079 0.87 LIPE (0.57) LIPEMAPTMAPK1TDP1L3MBTL1
SCHEMBL132403 0.85 LIPE (1.00) LIPEMAPTMAPK1TDP1L3MBTL1
SCHEMBL29591898 0.85 LIPE (1.00) LIPEMAPTMAPK1TDP1L3MBTL1
SCHEMBL339812 0.79 MAPT (0.71) LIPEMAPTMAPK1TDP1L3MBTL1
SCHEMBL5096393 0.75 LIPE (0.75) LIPEMAPTMAPK1TDP1L3MBTL1
SCHEMBL27403574 0.75 LIPE (0.75) LIPEMAPTMAPK1TDP1L3MBTL1
SCHEMBL22703367 0.75 LIPE (0.75) LIPEMAPTMAPK1TDP1L3MBTL1
SCHEMBL2157681 0.74 LIPE (0.73) LIPEMAPTMAPK1TDP1L3MBTL1
SCHEMBL19612191 0.74 MAPT (1.00) LIPEMAPTMAPK1TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9108989-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-08-18 — — US disclosed
US-20140121183-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2014-05-01 — — US disclosed
US-8629125-B2 Inhibitors of fatty acid amide hydrolase Infinty Pharmaceuticals, Inc. (US) 2014-01-14 — — US disclosed
US-20130059819-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2013-03-07 — — US disclosed
US-8349814-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2013-01-08 — — US disclosed
US-20120149693-A1 THERAPEUTIC COMPOUNDS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2012-06-14 — — US disclosed
US-20110230440-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE ADAMS JULIAN 2011-09-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120149693-A1 THERAPEUTIC COMPOUNDS HTR2C, GRK2, GRK3 LIPE 3056/4885MAPT 2718/4885MAPK1 2307/4885
US-20140121183-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 LIPE 88/4885MAPT 2853/4885MAPK1 3403/4885
US-20110230440-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 LIPE 88/4885MAPT 2853/4885MAPK1 3403/4885
US-20130059819-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 LIPE 88/4885MAPT 2853/4885MAPK1 3403/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.