Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9946167 | 0.87 | HPGD (0.59) | HPGDALDH1A1L3MBTL1MAPK1TSHR | |
| SCHEMBL1238180 | 0.81 | ALDH1A1 (0.40) | HPGDALDH1A1SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL1235917 | 0.81 | ALDH1A1 (0.40) | HPGDALDH1A1SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL10720943 | 0.79 | PHGDH (0.81) | PHGDHHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1017455 | 0.75 | PHGDH (0.69) | PHGDHHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL12871 | 0.75 | PHGDH (0.69) | PHGDHHPGDALDH1A1SMN1; SMN2KDM4E | |
| (4-Chlorophenyl)(Morpholino)Methanone SCHEMBL6937394 | 0.75 | PHGDH (1.00) | PHGDHHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28296651 | 0.74 | HPGD (0.86) | PHGDHHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL951497 | 0.74 | PHGDH (0.55) | PHGDHHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28273328 | 0.74 | MAOA (0.73) | PHGDHHPGDALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | PHGDH 3972/4885HPGD 2142/4885ALDH1A1 4010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.