Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9946562 | 0.79 | LMNA (0.42) | TSHRALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL9899917 | 0.76 | KDM4E (0.56) | RAB9ATSHRALDH1A1KDM4EGSK3A | |
| SCHEMBL1757730 | 0.75 | RAB9A (0.66) | RAB9ATSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1988320 | 0.74 | ALDH1A1 (0.66) | RAB9ATSHRALDH1A1KDM4EGSK3A | |
| SCHEMBL1987535 | 0.74 | RAB9A (0.54) | RAB9ATSHRALDH1A1KDM4EHPGD | |
| SCHEMBL2828050 | 0.73 | KDM4E (0.54) | RAB9ATSHRALDH1A1KDM4EGSK3A | |
| SCHEMBL11501036 | 0.73 | RAB9A (0.41) | RAB9ATSHRALDH1A1KDM4EGSK3A | |
| SCHEMBL10277241 | 0.73 | RAB9A (0.53) | RAB9ATSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7220336 | 0.72 | POLB (0.62) | RAB9ATSHRALDH1A1KDM4EGSK3A | |
| SCHEMBL11490023 | 0.72 | POLB (0.55) | RAB9ATSHRALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078210-A1 | CRTH2 MODULATORS AND PREPARATION THEREOF | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |