Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1325515 | 1.00 | MEN1 (0.43) | MEN1KMT2AALDH1A1SMN1; SMN2GABRB1 | |
| SCHEMBL1325516 | 1.00 | MEN1 (0.43) | MEN1KMT2AALDH1A1SMN1; SMN2GABRB1 | |
| SCHEMBL6041219 | 0.93 | MEN1 (0.40) | MEN1KMT2AALDH1A1SMN1; SMN2GABRB1 | |
| SCHEMBL6139041 | 0.87 | MEN1 (0.42) | MEN1KMT2AALDH1A1SMN1; SMN2GABRB1 | |
| SCHEMBL27597529 | 0.87 | MEN1 (0.42) | MEN1KMT2AALDH1A1SMN1; SMN2GABRB1 | |
| SCHEMBL8507676 | 0.86 | SMN1; SMN2 (0.41) | MEN1KMT2AALDH1A1SMN1; SMN2GABRB1 | |
| SCHEMBL9382586 | 0.84 | SMN1; SMN2 (0.41) | MEN1KMT2AALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL642839 | 0.84 | SMN1; SMN2 (0.41) | MEN1KMT2AALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL8709208 | 0.84 | ALOX15 (0.42) | MEN1KMT2AALDH1A1SMN1; SMN2PPARG | |
| SCHEMBL8709207 | 0.84 | ALOX15 (0.42) | MEN1KMT2AALDH1A1SMN1; SMN2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058240-B2 | Biological active ligands of melanocortin receptors | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| EP-1642888-B1 | Compounds for modulating the RAGE receptor | TRANSTECH PHARMA INC (US) | 2011-11-02 | — | — | EP | disclosed |
| EP-2288733-A2 | A HIGH THROUGHPUT PROTEIN INTERACTION ASSAY | Merck Sharp & Dohme Corp. (US) | 2011-03-02 | — | — | EP | disclosed |
| US-20110014226-A1 | HIGH THROUGHPUT PROTEIN INTERACTION ASSAY | MERCK SHARP & DOHME CORP. | 2011-01-20 | — | — | US | disclosed |
| WO-2009117409-A2 | A HIGH THROUGHPUT PROTEIN INTERACTION ASSAY | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| US-20090176712-A1 | Peptides with Efficacy in Rescuing Melanocortin-4 Receptor Polymorphic Agonist Signaling | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-07-09 | — | — | US | disclosed |
| WO-2007123839-A2 | PEPTIDES WITH EFFICACY IN RESCUING MELANOCORTIN-4 RECEPTOR POLYMORPHIC AGONIST SIGNALING | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2007-11-01 | — | — | WO | disclosed |
| US-20060189578-A1 | Method for the synthesis of compounds of formula I and their uses thereof | TRANSTECH PHARMA (US) | 2006-08-24 | — | — | US | disclosed |
| US-20060148760-A1 | Method for the sysnthesis of compounds of formula I and their uses thereof | TRANSTECH PHARMA (US) | 2006-07-06 | — | — | US | disclosed |
| US-7067554-B2 | Method for the synthesis of compounds of formula I and their uses thereof | TRANSTECH PHARMA, INC. (US) | 2006-06-27 | — | — | US | disclosed |
| EP-0805816-B1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK AS (DK) | 2004-07-28 | — | — | EP | disclosed |
| US-20040097407-A1 | Method for the synthesis of compounds of formula I and their uses thereof | TRANSTECH PHARMA, INC. | 2004-05-20 | — | — | US | disclosed |
| US-6613801-B2 | Antiinflammatory agents; antidiabetic agents | TRANSTECH PHARMA, INC. | 2003-09-02 | — | — | US | disclosed |
| EP-1284959-A1 | COMPOUNDS FOR MODULATING THE RAGE RECEPTOR | TransTech Pharma, Inc. (US) | 2003-02-26 | — | — | EP | disclosed |
| US-6350767-B1 | GROWTH HORMONE RELEASE STIMULANT | NOVO NORDISK A/S (DK) | 2002-02-26 | — | — | US | disclosed |
| US-20020006957-A1 | Method for the synthesis of compounds of formula I and their uses thereof | TRANSTECH PHARMA, LLC | 2002-01-17 | — | — | US | disclosed |
| WO-2001092210-A1 | COMPOUNDS FOR MODULATING THE RAGE RECEPTOR | TRANS TECH PHARMA (US) | 2001-12-06 | — | — | WO | disclosed |
| US-6013658-A | ANIMAL GROWTH REGULATORS | NOVO NORDISK A/S (DK) | 2000-01-11 | — | — | US | disclosed |
| EP-0805816-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022997-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1996-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148760-A1 | Method for the sysnthesis of compounds of formula I and their uses thereof | AGER, S100B, S100P | MEN1 1489/4885KMT2A 4877/4885ALDH1A1 3074/4885 |
| US-20060189578-A1 | Method for the synthesis of compounds of formula I and their uses thereof | AGER, S100B, S100P | MEN1 1705/4885KMT2A 4875/4885ALDH1A1 2326/4885 |
| US-20020006957-A1 | Method for the synthesis of compounds of formula I and their uses thereof | AGER, S100B, S100P | MEN1 1728/4885KMT2A 4873/4885ALDH1A1 2332/4885 |
| US-20040097407-A1 | Method for the synthesis of compounds of formula I and their uses thereof | AGER, S100B, S100P | MEN1 1728/4885KMT2A 4873/4885ALDH1A1 2332/4885 |
| US-20110014226-A1 | HIGH THROUGHPUT PROTEIN INTERACTION ASSAY | SSB, AIP, LY96 | MEN1 2079/4885KMT2A 1570/4885ALDH1A1 4535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.