Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.58 |
| ▸ | MMP1 | P03956 | 8/20 | 0.58 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | MMP2 | P08253 | 7/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.50 |
| ▸ | MMP8 | P22894 | 5/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | MMP7 | P09237 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417423 | 0.81 | MMP13 (0.54) | MMP13MMP1PKMMMP2MMP9 | |
| SCHEMBL7411621 | 0.81 | MMP13 (0.57) | MMP13MMP1PKMMMP2MMP9 | |
| SCHEMBL4195254 | 0.80 | PKM (0.61) | MMP13MMP1PKMMMP2MMP9 | |
| SCHEMBL10762585 | 0.79 | MMP13 (0.51) | MMP13MMP1PKMMMP2MMP9 | |
| SCHEMBL25678915 | 0.79 | GAA (0.48) | MMP13MMP1MMP2MMP9MMP8 | |
| SCHEMBL6929276 | 0.77 | MMP1 (0.70) | MMP13MMP1PKMMMP2MMP9 | |
| SCHEMBL14350865 | 0.76 | PKM (0.52) | MMP13MMP1PKMMMP2MMP9 | |
| SCHEMBL7352846 | 0.76 | MMP13 (0.60) | MMP13MMP1PKMMMP2MMP9 | |
| SCHEMBL7207763 | 0.76 | MMP1 (0.49) | MMP13MMP1MMP2MMP9MMP8 | |
| SCHEMBL9732631 | 0.75 | PKM (0.59) | MMP13MMP1PKMMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2654791-A1 | METHODS FOR TREATING SYSTEMIC LUPUS ERYTHEMATOSUS USING HIV PROTEASE INHIBITORS | The Feinstein Institute for Medical Research (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012088305-A1 | METHODS FOR TREATING SYSTEMIC LUPUS ERYTHEMATOSUS USING HIV PROTEASE INHIBITORS | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) | 2012-06-28 | — | — | WO | disclosed |