Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TPMT | P51580 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952080 | 0.83 | NCOA1 (0.35) | ALDH1A1KDM4EGAATSHRAPOBEC3A | |
| SCHEMBL28712875 | 0.82 | ALDH1A1 (0.39) | ALDH1A1TPMTKDM4EGAATSHR | |
| SCHEMBL9953202 | 0.79 | PIK3CD (0.42) | PIK3CD | |
| SCHEMBL21517191 | 0.79 | CA2 (0.31) | — | |
| SCHEMBL9953098 | 0.78 | LMNA (0.31) | ALDH1A1KDM4EGAANCOA1NCOA3 | |
| SCHEMBL9929298 | 0.78 | PDE2A (0.33) | ALDH1A1IMPDH2HSD17B10HPGDPIK3CD | |
| SCHEMBL9928957 | 0.78 | LMNA (0.37) | ALDH1A1HTTPIK3CD | |
| SCHEMBL9952654 | 0.78 | PIK3CD (0.40) | PIK3CD | |
| Hydrochloric Acid SCHEMBL9929353 | 0.77 | LMNA (0.36) | ALDH1A1GAAHTTPIK3CD | |
| SCHEMBL20816035 | 0.77 | HSD17B10 (0.35) | ALDH1A1TPMTKDM4EGAAIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |