Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952080 | 0.85 | NCOA1 (0.35) | LMNAMAPK1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9952276 | 0.78 | ALDH1A1 (0.33) | KDM4EALDH1A1GAANCOA1NCOA3 | |
| SCHEMBL9953096 | 0.70 | ALDH1A1 (0.32) | SMN1; SMN2KDM4EALDH1A1GAANCOA1 | |
| SCHEMBL22047642 | 0.69 | AAK1 (0.40) | LMNASMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL9967834 | 0.69 | AAK1 (0.40) | LMNASMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL9953105 | 0.69 | AAK1 (0.38) | KDM4EALDH1A1GAA | |
| SCHEMBL9929298 | 0.68 | PDE2A (0.33) | LMNAALDH1A1 | |
| SCHEMBL9928957 | 0.68 | LMNA (0.37) | LMNAALDH1A1 | |
| SCHEMBL17333103 | 0.68 | IMPDH2 (0.32) | KDM4EALDH1A1 | |
| SCHEMBL9928938 | 0.68 | IMPDH2 (0.32) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |