Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.33 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952363 | 0.83 | IMPDH2 (0.38) | PIK3CDMAOB | |
| Hydrochloric Acid SCHEMBL17337368 | 0.78 | PIK3CD (0.53) | PIK3CD | |
| SCHEMBL9928762 | 0.77 | PIK3CD (0.42) | PIK3CDINPPL1 | |
| SCHEMBL9928927 | 0.75 | PRKAB2 (0.39) | PIK3CD | |
| SCHEMBL12813269 | 0.73 | PIK3CD (0.49) | TAAR1CYP1A2PIK3CD | |
| SCHEMBL9952939 | 0.70 | CYP11B2 (0.34) | PIK3CD | |
| SCHEMBL9952029 | 0.69 | TAAR1 (0.46) | TAAR1CYP1A2HTR2AHTR2CHTR2B | |
| SCHEMBL14742313 | 0.68 | PIK3CD (0.53) | PIK3CD | |
| SCHEMBL14742496 | 0.68 | PIK3CD (0.55) | PIK3CD | |
| SCHEMBL9953797 | 0.68 | PARP10 (0.39) | TAAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |