Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 3/20 | 0.41 |
| ▸ | IDO2 | Q6ZQW0 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 3/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955332 | 0.87 | HCAR1 (0.51) | LMNATP53ALDH1A1TDO2IDO2 | |
| SCHEMBL9954119 | 0.86 | HCAR1 (0.52) | LMNATDO2IDO2HCAR1 | |
| SCHEMBL9953432 | 0.85 | HCAR1 (0.55) | LMNATP53KDM4EALDH1A1HTT | |
| SCHEMBL9954105 | 0.85 | HCAR1 (0.53) | TP53TDO2IDO2HCAR1 | |
| SCHEMBL9954457 | 0.82 | HCAR1 (0.50) | HCAR1 | |
| SCHEMBL9954370 | 0.81 | L3MBTL1 (0.51) | LMNATP53ALDH1A1HTT | |
| SCHEMBL9953531 | 0.81 | PDE4D (0.42) | TDO2IDO2HCAR1 | |
| SCHEMBL9953657 | 0.81 | HCAR1 (0.56) | LMNAKDM4EALDH1A1TDO2IDO2 | |
| SCHEMBL9953534 | 0.81 | HCAR1 (0.43) | LMNATP53ALDH1A1TDO2IDO2 | |
| SCHEMBL9954540 | 0.79 | HCAR1 (0.58) | TDO2IDO2HCAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |