Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953693 | 0.87 | LMNA (0.47) | — | |
| SCHEMBL10517573 | 0.85 | NPC1 (0.46) | ESR2POLBNPC1 | |
| SCHEMBL9954066 | 0.85 | PI4KA (0.46) | POLBTRPV4CA12CA1CA2 | |
| SCHEMBL9954457 | 0.84 | HCAR1 (0.50) | ESR2NPC1CA12CA1CA2 | |
| SCHEMBL9954122 | 0.83 | ESR2 (0.44) | ESR2POLBNPC1CA12CA1 | |
| SCHEMBL9955025 | 0.82 | ESR2 (0.41) | ESR2POLBNPC1CA12CA1 | |
| SCHEMBL9953129 | 0.81 | POLB (0.41) | ESR2POLBCA12CA1CA2 | |
| SCHEMBL9954881 | 0.79 | TDO2 (0.52) | ESR2POLBNPC1 | |
| SCHEMBL9953657 | 0.78 | HCAR1 (0.56) | POLBHCAR1 | |
| SCHEMBL9953965 | 0.78 | POLB (0.41) | ESR2POLBNPC1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |