Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.52 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.52 |
| ▸ | MAT2A | P31153 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954672 | 0.85 | TDO2 (0.52) | TDO2IDO2AKR1C3MEN1KMT2A | |
| SCHEMBL10517573 | 0.84 | NPC1 (0.46) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL9954457 | 0.83 | HCAR1 (0.50) | ESR2NPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL9954122 | 0.82 | ESR2 (0.44) | MEN1KMT2APOLBESR2NPC1 | |
| SCHEMBL9954576 | 0.79 | ESR2 (0.41) | POLBESR2NPC1 | |
| SCHEMBL9955025 | 0.79 | ESR2 (0.41) | POLBESR2NPC1 | |
| SCHEMBL9953129 | 0.77 | POLB (0.41) | TDO2IDO2POLBPIK3CDESR2 | |
| SCHEMBL9953965 | 0.77 | POLB (0.41) | MEN1KMT2APOLBESR2NPC1 | |
| SCHEMBL9953877 | 0.75 | POLB (0.54) | MEN1KMT2AALDH1A1POLBESR2 | |
| SCHEMBL9954657 | 0.74 | HPD (0.44) | TDO2IDO2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |