Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | HPD | P32754 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27074564 | 0.86 | CA12 (0.45) | CA12CA1CA2CA9HDAC1 | |
| SCHEMBL9953155 | 0.84 | ATM (0.48) | HDAC1HDAC8HDAC6HDAC2HDAC10 | |
| SCHEMBL27074552 | 0.83 | CA12 (0.43) | CA12CA1CA2CA9HDAC1 | |
| SCHEMBL27074567 | 0.82 | CA12 (0.42) | CA12CA1CA2CA9HDAC1 | |
| SCHEMBL9953324 | 0.79 | HCAR1 (0.50) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL9954457 | 0.79 | HCAR1 (0.50) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL23958121 | 0.78 | ALOX12 (0.43) | CA12CA1CA2CA9MAPT | |
| SCHEMBL27074558 | 0.78 | POLB (0.42) | CA12CA1CA2CA9HDAC1 | |
| SCHEMBL31416020 | 0.78 | CA12 (0.46) | CA12CA1CA2CA9HDAC1 | |
| SCHEMBL27074571 | 0.78 | CA12 (0.46) | CA12CA1CA2CA9HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |