Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9955416 | 0.86 | TSHR (0.40) | TSHRSHMT2MEN1POLBKMT2A | |
| SCHEMBL9958946 | 0.78 | KMT2A (0.47) | MEN1KMT2AMAPT | |
| SCHEMBL9954790 | 0.78 | SHMT2 (0.41) | TSHRSHMT2MEN1POLBKMT2A | |
| SCHEMBL20680333 | 0.76 | SHMT2 (0.40) | TSHRSHMT2MEN1POLBKMT2A | |
| SCHEMBL27103224 | 0.76 | MEN1 (0.41) | TSHRSHMT2MEN1POLBKMT2A | |
| SCHEMBL1502532 | 0.76 | CA12 (0.44) | TSHRSHMT2MEN1POLBKMT2A | |
| SCHEMBL9954653 | 0.76 | ALDH1A1 (0.48) | MEN1POLBKMT2AEDNRAMAPT | |
| Ammonia Solution, Strong SCHEMBL27875820 | 0.75 | CA12 (0.42) | TSHRSHMT2MEN1POLBKMT2A | |
| SCHEMBL9954692 | 0.75 | SHMT2 (0.42) | SHMT2MEN1POLBKMT2ANPC1 | |
| SCHEMBL9954614 | 0.74 | ALPL (0.52) | ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |