Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035939 | 0.89 | MMP8 (0.49) | KMT2AMMP8ALDH1A1CYP1A2MEN1 | |
| SCHEMBL14147393 | 0.83 | MMP8 (0.50) | KMT2AMMP8ALDH1A1CYP1A2MEN1 | |
| SCHEMBL13724813 | 0.82 | KMT2A (0.45) | KMT2AMMP8ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL21573712 | 0.80 | ALDH1A1 (0.49) | KMT2AMMP8ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11526043 | 0.79 | MMP8 (0.41) | KMT2AMMP8ALDH1A1MEN1TDP1 | |
| SCHEMBL27152475 | 0.79 | NLRP3 (0.48) | KMT2AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13150211 | 0.78 | L3MBTL1 (0.49) | KMT2AALDH1A1NPSR1MEN1KDM4E | |
| SCHEMBL9954458 | 0.77 | CYP4F2 (0.47) | KMT2AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1246314 | 0.76 | KMT2A (0.63) | KMT2AALDH1A1MEN1ATMTDP1 | |
| SCHEMBL16218019 | 0.76 | TDP1 (0.50) | KMT2AMMP8ALDH1A1CYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655365-B1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | Acturum Life Science AB (SE) | 2015-12-16 | — | — | EP | disclosed |
| EP-2655365-B1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | Acturum Life Science AB (SE) | 2015-12-16 | — | — | EP | disclosed |
| US-9012457-B2 | 2-carboxamide-4-piperazinyl-benzofuran derivative | ASTRAZENECA AB (SE) | 2015-04-21 | — | — | US | disclosed |
| US-9012457-B2 | 2-carboxamide-4-piperazinyl-benzofuran derivative | ASTRAZENECA AB (SE) | 2015-04-21 | — | — | US | disclosed |
| US-9012457-B2 | 2-carboxamide-4-piperazinyl-benzofuran derivative | ASTRAZENECA AB (SE) | 2015-04-21 | — | — | US | disclosed |
| US-20140329830-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2014-11-06 | — | — | US | disclosed |
| US-20140329830-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2014-11-06 | — | — | US | disclosed |
| US-20140329830-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2014-11-06 | — | — | US | disclosed |
| EP-2655365-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | AstraZeneca AB (SE) | 2013-10-30 | — | — | EP | disclosed |
| CN-103380129-A | 2-carboxamide-4-piperazinyl-benzofuran derivative | ASTRAZENECA AB | 2013-10-30 | — | — | CN | disclosed |
| WO-2012087229-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087229-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329830-A1 | 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE | GRIN2C, BDNF, GRIN2A | KMT2A 390/4885MMP8 4309/4885ALDH1A1 436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.