Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29090337 | 1.00 | THRB (0.41) | THRBATMMAPTCYP3A4CYP2C9 | |
| SCHEMBL28407513 | 0.94 | THRB (0.37) | THRBATMMAPTCYP3A4CYP2C9 | |
| SCHEMBL3649807 | 0.88 | ATM (0.37) | THRBATMPARP10 | |
| SCHEMBL28516952 | 0.88 | ATM (0.37) | THRBATMPARP10 | |
| SCHEMBL28599850 | 0.88 | ATM (0.37) | THRBATMPARP10 | |
| SCHEMBL28453661 | 0.85 | ESR2 (0.36) | THRBATMPDE4APDE4BPDE4C | |
| SCHEMBL8805010 | 0.81 | THRB (0.45) | THRBMAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL19996621 | 0.81 | THRB (0.45) | THRBMAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28062771 | 0.79 | ATM (0.34) | ATMPARP10 | |
| SCHEMBL17374176 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024140431-A1 | COMPOUNDS COMPRISING HETEROARYL RINGS AND COMPOSITIONS AND METHODS THEREOF | IONGEN THERAPEUTICS CO., LTD. (CN) | 2024-07-04 | — | — | WO | disclosed |
| CN-114315834-B | Imidazolone derivatives and their use in medicine | 成都百裕制药股份有限公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-117015528-A | Indole derivatives as kinase inhibitors | GB005股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| EP-4225749-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | Cullgen (Shanghai), Inc. (CN) | 2023-08-16 | — | — | EP | disclosed |
| CN-116490506-A | Fused tricyclic compounds, process for their preparation and their use in medicine | 江苏恒瑞医药股份有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-113121538-B | Furan derivative and application thereof in medicine | 成都百裕制药股份有限公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-114364664-A | BCAT modulation | 伊卡根有限责任公司 | 2022-04-15 | — | — | CN | disclosed |
| WO-2022073469-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | CULLGEN (SHANGHAI) , INC. (CN) | 2022-04-14 | — | — | WO | disclosed |
| CN-114315834-A | Imidazolidinone derivatives and their use in medicaments | 成都百裕制药股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-107674071-B | Carbazole-containing sulfonamides as cryptochrome modulators | 同步制药公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-107602564-A | Bruton's tyrosine kinase inhibitor | 南京亘泰医药技术有限公司 | 2018-01-19 | — | — | CN | disclosed |
| CN-104640855-B | Complement is by way of conditioning agent and application thereof | 诺华股份有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-105980383-B | Azaindole derivatives | 大鹏药品工业株式会社 | 2017-07-04 | — | — | CN | disclosed |
| CN-106170290-A | Substituted di-amino-pyrimidine based compound, combinations thereof and treatment method thereof | 西格诺药品有限公司 | 2016-11-30 | — | — | CN | disclosed |
| WO-2016161960-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE, LTD. (KY) | 2016-10-13 | — | — | WO | disclosed |
| CN-105980383-A | Azaindole derivatives | 大鹏药品工业株式会社 | 2016-09-28 | — | — | CN | disclosed |
| CN-105849099-A | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) | 达纳-法伯癌症研究所股份有限公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-104640855-A | Complement pathway modulators and uses thereof | NOVARTIS AG | 2015-05-20 | — | — | CN | disclosed |
| EP-2654748-A1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087772-A1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |