Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995182 | 0.80 | L3MBTL1 (0.43) | ADRA2AADRA2BADRA2CDRD2SLC6A4 | |
| SCHEMBL12130571 | 0.78 | TDP1 (0.45) | SLC6A4HRH3SLC6A2 | |
| SCHEMBL12130553 | 0.76 | SLC6A2 (0.42) | LTA4HOPRM1OPRL1SLC6A4HRH3 | |
| SCHEMBL994992 | 0.76 | SLC6A4 (0.48) | LTA4HADRA2AADRA2BDRD2OPRM1 | |
| SCHEMBL991525 | 0.75 | HTR7 (0.47) | DRD2ALDH1A1HRH3CYP1A2CYP2D6 | |
| SCHEMBL12130554 | 0.75 | HRH3 (0.43) | LTA4HOPRM1OPRL1SLC6A4HRH3 | |
| SCHEMBL12130449 | 0.75 | HRH3 (0.43) | LTA4HOPRM1OPRL1SLC6A4HRH3 | |
| SCHEMBL991769 | 0.74 | HTR7 (0.39) | DRD2SLC6A4ALDH1A1HRH3SLC6A2 | |
| SCHEMBL994382 | 0.74 | SLC6A2 (0.45) | LTA4HSLC6A4ALDH1A1HRH3SLC6A2 | |
| SCHEMBL12130575 | 0.73 | PTGES (0.44) | ADRA2AADRA2BADRA2CPPARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008666-A2 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-01-20 | — | — | WO | disclosed |