Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.47 |
| ▸ | HTR6 | P50406 | 7/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995182 | 0.89 | L3MBTL1 (0.43) | HTR7HTR6DRD2HTR2AALDH1A1 | |
| SCHEMBL991769 | 0.88 | HTR7 (0.39) | HTR7HTR6DRD2HTR2AALDH1A1 | |
| SCHEMBL1079151 | 0.82 | HTR7 (0.54) | HTR7HTR6DRD2HTR2AALDH1A1 | |
| SCHEMBL1079153 | 0.82 | HTR7 (0.54) | HTR7HTR6DRD2HTR2AALDH1A1 | |
| SCHEMBL998132 | 0.79 | ALDH1A1 (0.43) | HTR7HTR6DRD2HTR2AALDH1A1 | |
| SCHEMBL12130571 | 0.79 | TDP1 (0.45) | HTR7HTR6HTR2AKMT2AHTR1D | |
| SCHEMBL12130575 | 0.77 | PTGES (0.44) | ALDH1A1KMT2AHRH3SIGMAR1 | |
| SCHEMBL12130459 | 0.76 | HRH3 (0.43) | SMN1; SMN2KMT2AHRH3 | |
| SCHEMBL995782 | 0.75 | LTA4H (0.40) | DRD2ALDH1A1HRH3CYP1A2CYP2D6 | |
| SCHEMBL992649 | 0.75 | HRH3 (0.40) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008666-A2 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-01-20 | — | — | WO | disclosed |