Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TRIM24 | O15164 | 10/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3156959 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2ATRIM24LMNA | |
| SCHEMBL9959634 | 0.80 | MAPT (0.50) | SMN1; SMN2KMT2ATRIM24LMNAALDH1A1 | |
| SCHEMBL9960391 | 0.79 | ALDH1A1 (0.45) | TRIM24ALDH1A1 | |
| SCHEMBL9959434 | 0.78 | NLRP3 (0.51) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9958499 | 0.78 | NAMPT (0.47) | KMT2ATRIM24 | |
| SCHEMBL9958328 | 0.75 | HTR6 (0.53) | NPSR1 | |
| SCHEMBL9957615 | 0.74 | HTR6 (0.53) | — | |
| SCHEMBL10240546 | 0.73 | ESR2 (0.54) | SMN1; SMN2LMNATHRBALDH1A1NPSR1 | |
| SCHEMBL13757743 | 0.72 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1KMT2ALMNAHPGD | |
| SCHEMBL7284689 | 0.72 | ESR2 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081600-B1 | Combination of the NMDA- receptor ligand memantine and a compound with 5-HT6 receptor affinity | ESTEVE LABOR DR (ES) | 2012-12-05 | — | — | EP | claimed |
| EP-2007729-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2012-06-27 | — | — | EP | claimed |