Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 3/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KCNA1 | Q09470 | 2/20 | 0.38 |
| ▸ | KCNAB1 | Q14722 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 4/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9960391 | 0.88 | ALDH1A1 (0.45) | TRIM24RORCALDH1A1BRD4 | |
| SCHEMBL3142771 | 0.85 | ESR2 (0.53) | MAPTTRIM24LMNAKCNA1KCNAB1 | |
| SCHEMBL9959434 | 0.82 | NLRP3 (0.51) | MAPTLMNAKCNA1KCNAB1ALDH1A1 | |
| SCHEMBL9958481 | 0.80 | SMN1; SMN2 (0.52) | TRIM24LMNANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5242130 | 0.80 | MAPT (0.51) | MAPTTRIM24RORCLMNAKCNA1 | |
| SCHEMBL9958499 | 0.79 | NAMPT (0.47) | TRIM24KCNA1KCNAB1CYP1A2CYP3A4 | |
| SCHEMBL13757713 | 0.79 | DRD2 (0.50) | MAPTLMNAKCNA1KCNAB1NPSR1 | |
| Hydrochloric Acid SCHEMBL3147505 | 0.78 | DRD2 (0.49) | MAPTLMNAKCNA1KCNAB1NPSR1 | |
| SCHEMBL10240588 | 0.77 | DRD2 (0.51) | MAPTTRIM24LMNARECQLNPSR1 | |
| SCHEMBL9958328 | 0.76 | HTR6 (0.53) | NPSR1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081600-B1 | Combination of the NMDA- receptor ligand memantine and a compound with 5-HT6 receptor affinity | ESTEVE LABOR DR (ES) | 2012-12-05 | — | — | EP | claimed |
| EP-2007729-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2012-06-27 | — | — | EP | claimed |