Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959313 | 0.94 | KCNA5 (0.48) | ALDH1A1KCNA5LMNAMAPTMEN1 | |
| SCHEMBL10153706 | 0.92 | PRMT5 (0.43) | ALDH1A1TSHRLMNAMAPTL3MBTL1 | |
| SCHEMBL10153600 | 0.90 | MAPT (0.44) | ALDH1A1TSHRLMNAMAPTMEN1 | |
| SCHEMBL9959558 | 0.90 | KCNA5 (0.46) | ALDH1A1KCNA5LMNAMAPTMEN1 | |
| SCHEMBL9959556 | 0.87 | PRMT5 (0.46) | ALDH1A1TSHRMAPTL3MBTL1PRMT5 | |
| SCHEMBL9959530 | 0.85 | ALDH1A1 (0.43) | ALDH1A1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL9959606 | 0.84 | NPC1 (0.52) | ALDH1A1MAPTL3MBTL1KMT2APOLB | |
| SCHEMBL9959528 | 0.83 | L3MBTL1 (0.37) | ALDH1A1TSHRLMNAMAPTL3MBTL1 | |
| SCHEMBL21074868 | 0.83 | ALDH1A1 (0.43) | ALDH1A1TSHRLMNAMAPTL3MBTL1 | |
| SCHEMBL9959297 | 0.82 | HDAC4 (0.49) | ALDH1A1KCNA5TSHRMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |