Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.42 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.42 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.42 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958824 | 0.90 | ALDH1A1 (0.44) | MAPTTSHRALDH1A1KMT2ARAB9A | |
| SCHEMBL10153976 | 0.85 | TP53 (0.56) | MAPTALDH1A1KMT2APLAAT3PLAAT5 | |
| SCHEMBL10153642 | 0.85 | KCNA5 (0.42) | MAPTTSHRALDH1A1KMT2ALMNA | |
| SCHEMBL9959313 | 0.83 | KCNA5 (0.48) | MAPTALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL9958882 | 0.83 | KMT2A (0.46) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL9959312 | 0.83 | DRD2 (0.41) | MAPTTSHRALDH1A1KMT2ANPC1 | |
| SCHEMBL10153706 | 0.82 | PRMT5 (0.43) | MAPTTSHRALDH1A1KMT2ARAB9A | |
| SCHEMBL10153729 | 0.82 | MAPT (0.46) | MAPTTSHRALDH1A1TAAR1KMT2A | |
| SCHEMBL10154063 | 0.82 | KMT2A (0.47) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL10153579 | 0.81 | KMT2A (0.47) | MAPTALDH1A1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |