Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28312517 | 0.84 | GRM2 (0.38) | CYP2C19GRM2GRM3GRM4CYP1A2 | |
| SCHEMBL11412763 | 0.77 | CYP2C19 (0.42) | CYP2C19GRM2GRM3GRM4CYP1A2 | |
| SCHEMBL11033875 | 0.76 | CYP4F2 (0.41) | CYP2C19GRM2GRM3GRM4CYP1A2 | |
| SCHEMBL1652739 | 0.74 | CYP2C19 (0.40) | CYP2C19GRM2GRM3GRM4CYP1A2 | |
| SCHEMBL9959154 | 0.73 | CYP4F2 (0.44) | — | |
| SCHEMBL6273845 | 0.72 | TBXAS1 (0.42) | CYP2C19TBXAS1 | |
| SCHEMBL6267731 | 0.72 | CYP2C19 (0.47) | CYP2C19TBXAS1 | |
| SCHEMBL7370641 | 0.71 | MEN1 (0.39) | LMNASLC6A3KDM4E | |
| SCHEMBL1535484 | 0.71 | THRB (0.35) | CYP2C19GRM2GRM3GRM4CYP1A2 | |
| SCHEMBL13738211 | 0.69 | CYP2C19 (0.40) | CYP2C19GRM2GRM3GRM4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3263566-A1 | BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AS ALLOSTERIC MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLU5 OR MGLUR5) FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISORDERS | H. Lundbeck A/S (DK) | 2018-01-03 | — | — | EP | disclosed |
| US-20170217950-A1 | Bicyclo[3.2.1]Octyl Amide Derivatives and Uses of Same | H. LUNDBECK A/S (DK) | 2017-08-03 | — | — | US | disclosed |
| EP-2654422-B1 | Bicyclo[3.2.1]octyl amide derivatives as allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 or mGluR5) for the treatment of central nervous system (CNS) disorders | H LUNDBECK AS (DK) | 2017-08-02 | — | — | EP | disclosed |
| US-9656975-B2 | Bicyclo[3.2.1]octyl amide derivatives and uses of same | H. LUNDBECK A/S (DK) | 2017-05-23 | — | — | US | disclosed |
| US-20160326154-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2016-11-10 | — | — | US | disclosed |
| US-9212165-B2 | Bicarbocyclic and tricarbocyclic ethynyl derivatives and uses of same | H. LUNDBECK A/S (DK) | 2015-12-15 | — | — | US | disclosed |
| US-20150057289-A1 | BICYCLO[3.2.1.]OCTYL AMIDE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2015-02-26 | — | — | US | disclosed |
| US-8921370-B2 | Bicyclo[3.2.1]octyl amide derivatives and uses of same | H. LUNDBECK A/S (DK) | 2014-12-30 | — | — | US | disclosed |
| US-20140350030-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2014-11-27 | — | — | US | disclosed |
| EP-2654422-A1 | BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AND USES OF SAME | H. Lundbeck A/S (DK) | 2013-10-30 | — | — | EP | disclosed |
| US-20120190686-A1 | BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2012-07-26 | — | — | US | disclosed |
| WO-2012088365-A1 | BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217950-A1 | Bicyclo[3.2.1]Octyl Amide Derivatives and Uses of Same | SLC10A1, CLIC1, ABCB11 | CYP2C19 63/4885GRM2 2822/4885GRM3 2679/4885 |
| US-20150057289-A1 | BICYCLO[3.2.1.]OCTYL AMIDE DERIVATIVES AND USES OF SAME | SLC10A1, CLIC1, ABCB11 | CYP2C19 87/4885GRM2 2753/4885GRM3 2737/4885 |
| US-20120190686-A1 | BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AND USES OF SAME | SLC10A1, CLIC1, ABCB11 | CYP2C19 63/4885GRM2 2822/4885GRM3 2679/4885 |
| US-20140350030-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | CBR1, CYCS, CYP3A43 | CYP2C19 32/4885GRM2 2103/4885GRM3 2887/4885 |
| US-20160326154-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | CBR1, CYCS, CYP3A43 | CYP2C19 32/4885GRM2 2103/4885GRM3 2887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.