Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153305 | 0.87 | MEN1 (0.46) | ALDH1A1POLBGAASMN1; SMN2MEN1 | |
| SCHEMBL9960564 | 0.87 | TRPA1 (0.38) | ALDH1A1PARK7ATMMEN1KMT2A | |
| SCHEMBL10153698 | 0.87 | ALDH1A1 (0.39) | ALDH1A1KDM4EUSP2GAAMEN1 | |
| SCHEMBL9958850 | 0.87 | MEN1 (0.43) | ALDH1A1POLBKCNA5KDM4EGAA | |
| SCHEMBL9959325 | 0.85 | APP (0.42) | ALDH1A1ACHEHPGDHSD17B10MEN1 | |
| SCHEMBL10153594 | 0.85 | ACHE (0.45) | ALDH1A1ACHEKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL9959556 | 0.83 | PRMT5 (0.46) | ALDH1A1POLBGAASMN1; SMN2MEN1 | |
| SCHEMBL10153293 | 0.83 | ACHE (0.45) | POLBACHEUSP2SMN1; SMN2MEN1 | |
| SCHEMBL9959735 | 0.82 | KMT2A (0.33) | ALDH1A1POLBACHESMN1; SMN2HSD17B10 | |
| SCHEMBL10153644 | 0.81 | ALDH1A1 (0.42) | ALDH1A1ACHEGAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |