SCHEMBL9961463

SCHEMBL9961463

CCCC[C@]1(CC)CS(=O)(=O)c2ccccc2[C@@H](c2ccccc2)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SLC10A2 Q12908 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL349300 1.00 SLC10A2 (1.00) SLC10A2
SCHEMBL1993533 1.00 SLC10A2 (1.00) SLC10A2
SCHEMBL349299 1.00 SLC10A2 (1.00) SLC10A2
Hydrochloric Acid SCHEMBL8378730 0.99 SLC10A2 (0.98) SLC10A2
SCHEMBL13334949 0.93 SLC10A2 (0.86) SLC10A2
SCHEMBL8379990 0.93 SLC10A2 (0.86) SLC10A2
SCHEMBL8381989 0.92 SLC10A2 (0.85) SLC10A2
SCHEMBL8200833 0.92 SLC10A2 (0.85) SLC10A2
Hydrochloric Acid SCHEMBL8380609 0.92 SLC10A2 (0.84) SLC10A2
SCHEMBL8204051 0.91 SLC10A2 (0.83) SLC10A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3266457-B1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES SHIRE HUMAN GENETIC THERAPIES (US) 2026-05-06 EP disclosed
EP-4424363-B1 METHODS FOR INCREASING GROWTH IN PEDIATRIC SUBJECTS HAVING CHOLESTATIC LIVER DISEASE MIRUM PHARMACEUTICALS INC (US) 2026-04-29 EP disclosed
US-12599602-B2 Methods for treating cholestasis MIRUM PHARMACEUTICALS, INC. 2026-04-14 US disclosed
US-12576079-B2 Methods for treating cholestasis MIRUM PHARMACEUTICALS, INC. 2026-03-17 US disclosed
US-20250360127-A1 METHODS FOR TREATING CHOLESTASIS MIRUM PHARMACEUTICALS, INC. (US) 2025-11-27 US disclosed
US-20250281482-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES SHIRE HUMAN GENETIC THERAPIES, INC. (US) 2025-09-11 US disclosed
US-20250282808-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE SHIRE HUMAN GENETIC THERAPIES, INC. (US) 2025-09-11 US disclosed
US-12350267-B2 Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases SHIRE HUMAN GENETIC THERAPIES, INC. (US) 2025-07-08 US disclosed
EP-4464376-A2 GENOTYPE AND DOSE-DEPENDENT RESPONSE TO AN ASBTI IN PATIENTS WITH BILE SALT EXPORT PUMP DEFICIENCY Mirum Pharmaceuticals, Inc. (US) 2024-11-20 EP disclosed
US-12145959-B2 Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease SHIRE HUMAN GENETIC THERAPIES, INC. (US) 2024-11-19 US disclosed
US-20130109671-A1 Bile Acid Recycling Inhibitors for Treatment of Pediatric Cholestatic Liver Diseases Lumena Pharmaceuticals, Inc. (US) 2013-05-02 US disclosed
US-20130108573-A1 Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease Lumena Pharmaceuticals, Inc. (US) 2013-05-02 US disclosed
US-20130059807-A1 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS SATIOGEN PHARMACEUTICALS, INC. (US) 2013-03-07 US disclosed
US-20130059807-A1 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS SATIOGEN PHARMACEUTICALS, INC. (US) 2013-03-07 US disclosed
WO-2013020108-A2 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PANCREATITIS Lumena Pharmaceuticals, Inc. (US) 2013-02-07 WO disclosed
US-20130034536-A1 Bile Acid Recycling Inhibitors for Treatment of Pancreatitis Lumena Pharmaceuticals, Inc. (US) 2013-02-07 US disclosed
US-20130034536-A1 Bile Acid Recycling Inhibitors for Treatment of Pancreatitis Lumena Pharmaceuticals, Inc. (US) 2013-02-07 US disclosed
US-20120157399-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF OBESITY AND DIABETES SATIOGEN PHARMACEUTICALS, INC. (US) 2012-06-21 US disclosed
US-20120157399-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF OBESITY AND DIABETES SATIOGEN PHARMACEUTICALS, INC. (US) 2012-06-21 US disclosed
US-20100130472-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF OBESITY AND DIABETES SATIOGEN PHARMACEUTICALS, INC. (US) 2010-05-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250281482-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES SLC10A1, SLC10A2, ABCB11 SLC10A2 2/4885
US-20120157399-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF OBESITY AND DIABETES SLC10A1, SLC10A2, ABCB11 SLC10A2 2/4885
US-12145959-B2 Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease SLC10A1, SLC10A2, ABCB11 SLC10A2 2/4885
US-20250360127-A1 METHODS FOR TREATING CHOLESTASIS SLC10A1, SLC10A2, NR1H4 SLC10A2 2/4885
US-12350267-B2 Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases SLC10A1, SLC10A2, ABCB11 SLC10A2 2/4885
US-20250282808-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE SLC10A1, SLC10A2, ABCB11 SLC10A2 2/4885
US-20130109671-A1 Bile Acid Recycling Inhibitors for Treatment of Pediatric Cholestatic Liver Diseases SLC10A1, SLC10A2, ABCB11 SLC10A2 2/4885
US-12599602-B2 Methods for treating cholestasis SLC10A1, SLC10A2, SLC10A6 SLC10A2 2/4885
US-12576079-B2 Methods for treating cholestasis SLC10A1, SLC10A2, SLC10A6 SLC10A2 2/4885
US-20130059807-A1 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS SLC10A2, GPR119, GPBAR1 SLC10A2 1/4885
US-20130034536-A1 Bile Acid Recycling Inhibitors for Treatment of Pancreatitis SLC10A2, SLC10A1, NR1H4 SLC10A2 1/4885
US-20100130472-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF OBESITY AND DIABETES SLC10A1, SLC10A2, ABCB11 SLC10A2 2/4885
US-20130108573-A1 Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease SLC10A1, SLC10A2, ABCB11 SLC10A2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.