Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10489040 | 0.82 | CYP2A6 (0.69) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL27874251 | 0.81 | CYP2A6 (0.58) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL7275100 | 0.79 | CYP2A6 (0.60) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL13083133 | 0.79 | CYP2A6 (0.60) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL21215867 | 0.79 | NQO2 (0.46) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL25028287 | 0.76 | CYP2A6 (0.56) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL12497570 | 0.76 | CYP2A6 (0.56) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL8665125 | 0.76 | CYP2A6 (0.60) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL17742293 | 0.76 | CYP2A6 (0.60) | CYP2A6IMPDH2HPGDHTTMEN1 | |
| SCHEMBL30869156 | 0.76 | MEN1 (0.71) | CYP2A6IMPDH2HPGDHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920063-B2 | Melampomagnolide B derivatives | BIOVENTURES, LLC (US) | 2018-03-20 | — | — | US | disclosed |
| US-9920063-B2 | Melampomagnolide B derivatives | BIOVENTURES, LLC (US) | 2018-03-20 | — | — | US | disclosed |
| US-20160368928-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | BIOVENTURES, LLC | 2016-12-22 | — | — | US | disclosed |
| US-9487536-B2 | Melampomagnolide B derivatives | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2016-11-08 | — | — | US | disclosed |
| US-20150203508-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | BIOVENTURES, LLC | 2015-07-23 | — | — | US | disclosed |
| US-20150173359-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | BAYER IP GMBH (DE) | 2015-06-25 | — | — | US | disclosed |
| US-20150173359-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | BAYER IP GMBH (DE) | 2015-06-25 | — | — | US | disclosed |
| US-9006265-B2 | Substituted fused pyrimidinones and dihydropyrimidinones | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006265-B2 | Substituted fused pyrimidinones and dihydropyrimidinones | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-8283368-B2 | Selective ligands for the dopamine 3 (D3) receptor and methods of using the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-09 | — | — | US | disclosed |
| US-20120157306-A1 | Substituted Fused Pyrimidinones and Dihydropyrimidinones | BAYER CROPSCIENCE AG (DE) | 2012-06-21 | — | — | US | disclosed |
| US-20110184033-A1 | Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-28 | — | — | US | disclosed |
| US-20110184033-A1 | Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-28 | — | — | US | disclosed |
| US-7919521-B2 | Five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis therapeutics | ACADEMIA SINICA (TW) | 2011-04-05 | — | — | US | disclosed |
| US-20090306174-A1 | Novel Five-Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis Therapeutics | ACADEMIA SINICA (TW) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203508-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | CMBL, MGMT, MMAB | CYP2A6 3292/4885IMPDH2 2142/4885HPGD 3681/4885 |
| US-20150173359-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | DHPS, FDPS, DPYD | CYP2A6 2231/4885IMPDH2 167/4885HPGD 130/4885 |
| US-20090306174-A1 | Novel Five-Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis Therapeutics | ACE2, ENGASE, DPP7 | CYP2A6 1803/4885IMPDH2 148/4885HPGD 1080/4885 |
| US-20160368928-A1 | MELAMPOMAGNOLIDE B DERIVATIVES | CMBL, MGMT, MMAB | CYP2A6 3292/4885IMPDH2 2142/4885HPGD 3681/4885 |
| US-20120157306-A1 | Substituted Fused Pyrimidinones and Dihydropyrimidinones | DHPS, FDPS, DPYD | CYP2A6 2231/4885IMPDH2 167/4885HPGD 130/4885 |
| US-20110184033-A1 | Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same | DRD3, HTR3C, HTR3A | CYP2A6 1059/4885IMPDH2 3736/4885HPGD 2081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.