Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9968477 | 0.84 | ALDH1A1 (0.43) | KMT2ARAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL9968569 | 0.82 | MAPK1 (0.44) | KMT2ARAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL9941581 | 0.81 | KMT2A (0.63) | KMT2APOLBALDH1A1HPGDMEN1 | |
| SCHEMBL9968476 | 0.74 | ALDH1A1 (0.47) | POLBKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL9968581 | 0.72 | KDM4E (0.43) | KMT2ARAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL11517004 | 0.70 | LMNA (0.46) | KMT2ARAB9APOLBNPC1ALDH1A1 | |
| SCHEMBL6078727 | 0.70 | CYP19A1 (0.50) | KMT2APOLBMEN1CYP19A1LMNA | |
| SCHEMBL15682651 | 0.69 | KEAP1 (0.64) | POLBKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL9941859 | 0.69 | MAPT (0.65) | KMT2APOLBALDH1A1HPGDMEN1 | |
| SCHEMBL9941510 | 0.69 | ALDH1A1 (0.66) | KMT2APOLBALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082862-A2 | ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2012-06-21 | — | — | WO | disclosed |