Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6080187 | 0.72 | HSD17B3 (0.60) | CA2MEN1KMT2A | |
| SCHEMBL6078892 | 0.72 | CA2 (0.77) | CA2MAPTMEN1KMT2A | |
| SCHEMBL6077882 | 0.72 | ALDH1A1 (0.77) | POLBMAPTMEN1KMT2A | |
| SCHEMBL108218 | 0.71 | ERCC1 (0.78) | POLBERCC1ERCC4MAPTSMN1; SMN2 | |
| SCHEMBL16863964 | 0.71 | TPSAB1 (0.59) | CYP19A1CA2POLBINSRIGF1R | |
| SCHEMBL6078797 | 0.71 | PRMT1 (0.67) | CA2MAPTKMT2ASIRT1PRMT1 | |
| SCHEMBL6078748 | 0.71 | PRMT1 (0.67) | CA2MAPTKMT2ASIRT1PRMT1 | |
| SCHEMBL15682651 | 0.70 | KEAP1 (0.64) | CYP19A1CA2POLBSMN1; SMN2LMNA | |
| SCHEMBL4489812 | 0.70 | LMNA (0.61) | CYP19A1POLBMAPTSMN1; SMN2LMNA | |
| SCHEMBL9968618 | 0.70 | KMT2A (0.47) | CYP19A1POLBMAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1181271-B1 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2005-01-19 | — | — | EP | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |